Sumatriptan Succinate Hemi(Ethanol Solvate)

1-(3-(2-(Dimethylammonio)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide succinate (sumatriptan succinate, HSum+·HSucc−) is a serotonin receptor agonist used to treat migraines. By the recrystallization of this substance from ethanol, its hemi(ethanol solvate), HSum+·HSucc−·0.5EtOH, was obtained. T...

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Published in:MolBank 2024-01, Vol.2024 (1), p.M1766
Main Authors: Buikin, Petr A, Vologzhanina, Anna V, Korlyukov, Alexander A
Format: Article
Language:English
Subjects:
Acetaldehyde
active pharmaceutical ingredient
Alcohol
Alcohol, Denatured
Analysis
Chemical synthesis
Crystals
Diffraction
Ethanol
Fourier transform infrared spectroscopy
H-bond propensity
Headaches
Hydrogen
Hydrogen bonding
Identification and classification
Infrared spectroscopy
Methods
Migraine
Pharmaceutical industry
Recrystallization
Serotonin
single-crystal X-ray diffraction
Solvents
Spectrum analysis
Structure
Sumatriptan
X-rays
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Korlyukov, Alexander A
description 1-(3-(2-(Dimethylammonio)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide succinate (sumatriptan succinate, HSum+·HSucc−) is a serotonin receptor agonist used to treat migraines. By the recrystallization of this substance from ethanol, its hemi(ethanol solvate), HSum+·HSucc−·0.5EtOH, was obtained. The solid was characterized by X-ray diffraction and FT-IR spectroscopy. In HSum+·HSucc−·0.5EtOH, solvent molecules link succinate anions into infinite O–H…O bonded chains, which are further connected by N–H…O interactions with cations into H-bonded layers.
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subjects Acetaldehyde
active pharmaceutical ingredient
Alcohol
Alcohol, Denatured
Analysis
Chemical synthesis
Crystals
Diffraction
Ethanol
Fourier transform infrared spectroscopy
H-bond propensity
Headaches
Hydrogen
Hydrogen bonding
Identification and classification
Infrared spectroscopy
Methods
Migraine
Pharmaceutical industry
Recrystallization
Serotonin
single-crystal X-ray diffraction
Solvents
Spectrum analysis
Structure
Sumatriptan
X-rays
title Sumatriptan Succinate Hemi(Ethanol Solvate)
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