Plasma Placental Growth Factor Concentrations Are Elevated Well in Advance of Type 2 Diabetes Mellitus Onset: Prospective Data From the WHS

Background Pathologic angiogenesis is a hallmark of type 2 diabetes mellitus (T2DM) microvascular complications and may modulate adipogenesis and precede the onset of clinical diabetes mellitus; however, longitudinal data are unavailable. Placental growth factor is a potent proangiogenic factor that...

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Bibliographic Details
Published in:Journal of the American Heart Association 2019-08, Vol.8 (15), p.e012790-e012790
Main Authors: Duran, Edward K, Cook, Nancy R, Bobadilla, Maria, Kim, Eunjung, Manson, JoAnn E, Buring, Julie E, Ridker, Paul M, Pradhan, Aruna D
Format: Article
Language:English
Subjects:
angiogenesis
Cohort Studies
diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Female
Humans
Middle Aged
Original Research
placenta growth factor
Placenta Growth Factor - blood
Prospective Studies
Time Factors
vascular disease
vascular growth factor
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Summary:Background Pathologic angiogenesis is a hallmark of type 2 diabetes mellitus (T2DM) microvascular complications and may modulate adipogenesis and precede the onset of clinical diabetes mellitus; however, longitudinal data are unavailable. Placental growth factor is a potent proangiogenic factor that stimulates the formation of mature and durable vessels but is understudied in human diseases. Methods and Results We conducted a prospective case-cohort study of baseline placental growth factor and incident T2DM within the WHS (Women's Health Study). A random sample of incident T2DM cases (n=491) occurring over a 15-year follow-up period was selected and compared with a reference subcohort (n=561). Case subjects were matched to the reference risk set on 5-year age groups and race. All subjects in this analysis were required to have a hemoglobin A
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.119.012790