Takayasu Arteritis: recent advances and clinical pitfalls

Takayasu arteritis (TA) is a rare idiopathic inflammatory disease of large size arteries, primarily affecting young women. Vasculitic lesions might cause arterial steno-occlusions or dilatation with significant morbidity and mortality. TA rarity may result in its frequent under-recognition and diagn...

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Bibliographic Details
Published in:Beyond rheumatology 2022-08, Vol.4
Main Authors: E. Tombetti, P. Sarzi-Puttini
Format: Article
Language:English
Subjects:
magnetic resonance
positron emission tomography
takayasu arteritis
vascular remodelling
vasculitis
Online Access:Get full text
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Summary:Takayasu arteritis (TA) is a rare idiopathic inflammatory disease of large size arteries, primarily affecting young women. Vasculitic lesions might cause arterial steno-occlusions or dilatation with significant morbidity and mortality. TA rarity may result in its frequent under-recognition and diagnostic delays. Key disease features are systemic inflammation, arterial inflammation and remodelling. They may not always occur together and are differentially targeted by therapies. Accordingly, serial imaging studies are required for exhaustive activity assessment and patient follow-up. The present review provides a practical approach to most frequent clinical pitfalls, including diagnosis, activity assessment, the use of imaging, and the therapeutic approaches, and highlighs the most important unmet needs.
ISSN:2612-5110
DOI:10.53238/br_20228_400