Inhaled anesthesia associated with reduced mortality in patients with stage III breast cancer: A population-based study

Patients diagnosed with stage III breast cancer often undergo surgery, radiation therapy, and chemotherapy as part of their treatment. The choice of anesthesia technique during surgery has been a subject of interest due to its potential association with immune changes and prognosis. In this study, w...

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Bibliographic Details
Published in:PloS one 2024-03, Vol.19 (3), p.e0289519-e0289519
Main Authors: Kuo, Emily Tzu-Jung, Kuo, Chin, Lin, Cheng-Li
Format: Article
Language:English
Subjects:
Analysis
Anesthesia
Anesthetics
Breast cancer
Cancer
Cancer patients
Care and treatment
Chemotherapy
Complications and side effects
Development and progression
Diagnosis
Dosage and administration
Evaluation
Homeopathy
Materia medica and therapeutics
Mortality
National health insurance
Oncology, Experimental
Online databases
Patient outcomes
Prognosis
Taiwan
Therapeutics
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Summary:Patients diagnosed with stage III breast cancer often undergo surgery, radiation therapy, and chemotherapy as part of their treatment. The choice of anesthesia technique during surgery has been a subject of interest due to its potential association with immune changes and prognosis. In this study, we aimed to compare the mortality rates between stage III breast cancer patients undergoing surgery with propofol-based intravenous general anesthesia and those receiving inhaled anesthetics. Using data from Taiwan's National Health Insurance Research Database and Taiwan Cancer Registry, we identified a cohort of 10,896 stage III breast cancer patients. Among them, 1,506 received propofol-based intravenous anesthetic maintenance, while 9,390 received inhaled anesthetic maintenance. To ensure comparability between the two groups, we performed propensity-score matching. Our findings revealed a significantly lower mortality rate in patients who received inhaled anesthetics compared to those who received propofol-based intravenous anesthesia. Sensitivity analysis further confirmed the robustness of our results. This study suggests that inhaled anesthesia technique is associated with a lower mortality rate in clinical stage III breast cancer. Further research is needed to validate and expand upon these results.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0289519