Structural Features Influencing the Bioactive Conformation of Angiotensin II and Angiotensin A: Relationship between Receptor Desensitization, Addiction, and the Blood-Brain Barrier

The N-terminal portion of the octapeptide angiotensin II (DRVYIHPF; AngII), a vasopressor peptide that favorably binds to, and activates, AngII type 1 receptor (AT R), has an important role in maintaining bioactive conformation. It involves all three charged groups, namely (i) the N-terminal amino g...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-06, Vol.25 (11), p.5779
Main Authors: Moore, Graham J, Ridway, Harry, Gadanec, Laura Kate, Apostolopoulos, Vasso, Zulli, Anthony, Swiderski, Jordan, Kelaidonis, Konstantinos, Vidali, Veroniki P, Matsoukas, Minos-Timotheos, Chasapis, Christos T, Matsoukas, John M
Format: Article
Language:English
Subjects:
Addiction
Addictions
Adrenergic receptors
Alcohol
Amino acids
Amphetamines
Analysis
angiotensin II
Angiotensin II - metabolism
Angiotensin II receptor blockers
Animals
arginine
Atherosclerosis
Biological activity
bisartan
Blood pressure
Blood-Brain Barrier - metabolism
blood–brain barrier
Cardiovascular disease
Care and treatment
Cocaine
conformation of angiotensin
Coronary vessels
Desensitization (Psychology)
Dopamine
Drug abuse
Enzymes
Homeostasis
Humans
Morphine
Multiple sclerosis
Nervous system
Neurons
Peptides
Prescription drugs
Protein Conformation
Receptor, Angiotensin, Type 1 - chemistry
Receptor, Angiotensin, Type 1 - metabolism
Smooth muscle
Substance abuse
T cell receptors
Vein & artery diseases
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Description
Summary:The N-terminal portion of the octapeptide angiotensin II (DRVYIHPF; AngII), a vasopressor peptide that favorably binds to, and activates, AngII type 1 receptor (AT R), has an important role in maintaining bioactive conformation. It involves all three charged groups, namely (i) the N-terminal amino group cation, (ii) the Asp sidechain anion and (iii) the Arg guanidino cation. Neutralization of any one of these three charged groups results in a substantial reduction (
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25115779