Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer

Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new combined gene. They have been implicated in carcinogenesis in a number of different cancers, though they have been understudied in high grade serous...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-04, Vol.22 (9), p.4791
Main Authors: Newtson, Andreea, Reyes, Henry, Devor, Eric J, Goodheart, Michael J, Bosquet, Jesus Gonzalez
Format: Article
Language:English
Subjects:
Cancer therapies
Carcinogenesis
Carcinogens
Cell cycle
Chemotherapy
Chromosome rearrangements
Chromosomes
Clinical outcomes
Comorbidity
Deoxyribonucleic acid
DNA
Drug resistance
Fallopian tubes
fusion genes
fusion transcripts
Gene expression
Genes
Genomics
high grade serous ovarian cancer
Medical prognosis
Multivariate analysis
Mutation
Nucleotide sequence
Ovarian cancer
Survival
Transcriptomes
Tumors
Variables
whole transcriptome sequencing
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Summary:Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new combined gene. They have been implicated in carcinogenesis in a number of different cancers, though they have been understudied in high grade serous ovarian cancer. This study used high throughput tools to compare the transcriptome of high grade serous ovarian cancer and normal fallopian tubes in the interest of identifying unique fusion transcripts within each group. Indeed, we found that there were significantly more fusion transcripts in the cancer samples relative to the normal fallopian tubes. Following this, the role of fusion transcripts in chemo-response and overall survival was investigated. This led to the identification of fusion transcripts significantly associated with overall survival. Validation was performed with different analytical platforms and different algorithms to find fusion transcripts.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22094791