Analysis of factors affecting the length of hospitalization of patients with Clostridioides difficile infection: a cross-sectional study

Clostridioides difficile infection (CDI) is an infectious disease caused by the gram-positive, anaerobic bacterium C. difficile. The vulnerable populations for CDI include the elderly, immunocompromised individuals, and hospitalized patients, especially those undergoing antimicrobial therapy, which...

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Published in:Archives of public health = Archives belges de santé publique 2024-09, Vol.82 (1), p.158-10, Article 158
Main Authors: Drobnik, Jarosław, Pobrotyn, Piotr, Moricová, Štefánia, Madziarska, Katarzyna, Baran, Mateusz
Format: Article
Language:English
Subjects:
Albumin
Aminoglycosides
Antibacterial agents
Bacterial pneumonia
Care and treatment
Clostridioides difficile infection
Communicable diseases
Diarrhea
Fidaxomicin
Health aspects
Hospital patients
Length of hospitalization
Length of stay
Medical records
Medical research
Medicine, Experimental
Metronidazole
Nutritional Risk Screening
Pneumonia
Risk factors
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Summary:Clostridioides difficile infection (CDI) is an infectious disease caused by the gram-positive, anaerobic bacterium C. difficile. The vulnerable populations for CDI include the elderly, immunocompromised individuals, and hospitalized patients, especially those undergoing antimicrobial therapy, which is a significant risk factor for this infection. Due to its complications and increased resistance to treatment, CDI often leads to longer hospital stays. This study aimed to determine the average length of hospital stay (LOS) of Polish patients with CDI and to identify factors affecting the LOS of infected patients. The study analyzed medical records of adult patients treated with CDI in one of the biggest clinical hospitals in Poland between 2016-2018. Information encompassed the patient's age, LOS results of selected laboratory tests, number of antibiotics used, nutritional status based on Nutritional Risk Screening (NRS 2002), year of hospitalization, presence of diarrhea on admission, systemic infections, additional conditions, and undergone therapies. The systematic collection of these variables forms the foundation for a comprehensive analysis of factors influencing the length of stay. In the study period, 319 patients with CDI were hospitalized, with a median LOS of 24 days (min-max = 2-344 days). The average LOS was 4.74 days in 2016 (median = 28 days), 4.27 days in 2017 (median = 24 days), and 4.25 days in 2018 (median = 23 days). There was a weak negative correlation (Rho = -0.235, p 
ISSN:0778-7367
2049-3258
2049-3258
DOI:10.1186/s13690-024-01392-4