Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response

Autophagy is an intracellular lysosomal degradation process performed by the cells to maintain energy balance. The autophagy response plays an important role in the progression of liver disease due to hepatitis virus infection, alcoholic liver disease, nonalcoholic fatty liver disease, liver cirrhos...

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Bibliographic Details
Published in:Hepatic medicine: evidence and research 2016-01, Vol.8 (Issue 1), p.9-20
Main Authors: Dash, Srikanta, Chava, Srinivas, Chandra, Partha K, Aydin, Yucel, Balart, Luis A, Wu, Tong
Format: Article
Language:English
Subjects:
Adaptive immunity
Anopheles
Apoptosis
Autophagy
autophagy inhibitor
Cancer
Cancer therapies
Carcinoma
Chemotherapy
chloroquine
Cytoplasm
Development and progression
Endoplasmic reticulum
Energy
Enzymes
Fatty liver
Health aspects
Hepatitis
Hepatocellular carcinoma
hydroxychloroquine
Immune response
Infection
Inflammation
Kinases
Laboratory animals
Liver
Liver cancer
Liver cirrhosis
Liver diseases
macroautophagy
microautophagy
Novels
Pathogenesis
Phosphorylation
Proteins
Review
Sorafenib
Virus diseases
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Summary:Autophagy is an intracellular lysosomal degradation process performed by the cells to maintain energy balance. The autophagy response plays an important role in the progression of liver disease due to hepatitis virus infection, alcoholic liver disease, nonalcoholic fatty liver disease, liver cirrhosis, and hepatocellular carcinoma (HCC). An increased autophagy response also contributes to the pathogenesis of liver disease through modulation of innate and adaptive immune responses; a defective cellular autophagy response leads to the development of HCC. Recent progress in the field indicates that autophagy modulation provides a novel targeted therapy for human liver cancer. The purpose of this review is to update our understanding of how the cellular autophagy response impacts the pathophysiology of liver disease and HCC treatment.
ISSN:1179-1535
1179-1535
DOI:10.2147/HMER.S63700