High Expression of CEMIP Correlates Poor Prognosis and the Tumur Microenvironment in Breast Cancer as a Promisingly Prognostic Biomarker

Cell migration-inducing hyaluronidase 1 (CEMIP), a Wnt-related protein and also known as KIAA1199, is implicated in the process of metastatic colonization in a variety of malignant tumors, including breast cancer (BC), which is one of the most frequently diagnosed tumors in women worldwide. In this...

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Bibliographic Details
Published in:Frontiers in genetics 2021-12, Vol.12, p.768140-768140
Main Authors: Dong, Xingxing, Yang, Yalong, Yuan, Qianqian, Hou, Jinxuan, Wu, Gaosong
Format: Article
Language:English
Subjects:
biomarker
breast cancer
CEMIP
Genetics
prognosis
tumor microenvironment
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Summary:Cell migration-inducing hyaluronidase 1 (CEMIP), a Wnt-related protein and also known as KIAA1199, is implicated in the process of metastatic colonization in a variety of malignant tumors, including breast cancer (BC), which is one of the most frequently diagnosed tumors in women worldwide. In this study, multiple public databases, online analytical tools, and bioinformatics approaches were applied to explore the expression levels, regulatory mechanisms, and biological functions of CEMIP in BC. We illustrated that was highly expressed in various kinds of carcinomas, including BC, especially advanced subtypes, and predicted less favorable prognosis (negatively associated with overall survival) in BC patients, which might be an independent prognostic factor. Then, we revealed that the mutation and high expression of might lead to it as an oncogene. We also demonstrated that mutation, DNA hypo-methylation, and the expression changes of three potential upstream transcription factors ( , and ) of were likely to cause the hyperexpression of in BC Moreover, our findings suggested that CEMIP might exert its carcinogenic roles in the tumor microenvironment via participation in the extracellular matrix formation, increasing cancer-associated fibroblast (CAF), M2 macrophage, and neutrophil infiltration and decreasing CD8 T cell infiltration. In summary, our study provided more solid evidence for CEMIP as a prognostic and metastatic biomarker and a potential therapeutic target in BC. Of course, these findings also need more confirmations of basic experiments and further clinical trials in the future.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2021.768140