Risks and benefits of sex-mismatched hematopoietic cell transplantation differ according to conditioning strategy

Sex-mismatched hematopoietic cell transplantation is linked to increased graft-versus-host disease and mortality in myeloablative conditioning. Here we evaluated outcomes of 1,041 adult transplant recipients at two centers between 2006 and 2013 and investigated how the effect of sex-mismatching diff...

Full description

Saved in:
Bibliographic Details
Published in:Haematologica (Roma) 2015-11, Vol.100 (11), p.1477-1485
Main Authors: Nakasone, Hideki, Remberger, Mats, Tian, Lu, Brodin, Petter, Sahaf, Bita, Wu, Fang, Mattsson, Jonas, Lowsky, Robert, Negrin, Robert, Miklos, David B, Meyer, Everett
Format: Article
Language:English
Subjects:
Adult
Disease-Free Survival
Female
Graft vs Host Disease - mortality
Graft vs Host Disease - therapy
Hematologic Neoplasms - mortality
Hematologic Neoplasms - therapy
Humans
Male
Medicin och hälsovetenskap
Peripheral Blood Stem Cell Transplantation
Sex Factors
Survival Rate
Transplantation Conditioning
Unrelated Donors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sex-mismatched hematopoietic cell transplantation is linked to increased graft-versus-host disease and mortality in myeloablative conditioning. Here we evaluated outcomes of 1,041 adult transplant recipients at two centers between 2006 and 2013 and investigated how the effect of sex-mismatching differed in myeloablative, reduced-intensity, and non-myeloablative total lymphoid irradiation with anti-thymocyte globulin conditioning. Among patients who underwent myeloablative conditioning, male recipients with female donors had increased chronic graft-versus-host disease (hazard ratio 1.83, P
ISSN:0390-6078
1592-8721
1592-8721
DOI:10.3324/haematol.2015.125294