Molecular typing of Mycobacterium tuberculosis strains with a common two-band IS6110 pattern

We conducted a program of population-based molecular typing of all Mycobacterium tuberculosis isolates obtained in Alabama since 1994. Of 2452 isolates, 1013 (41%) had fewer than 6 bands of IS6110; 348 (14%) had a single two-band pattern (JH2). With conventional epidemiologic methods, we identified...

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Bibliographic Details
Published in:Emerging infectious diseases 2002-11, Vol.8 (11), p.1303-1305
Main Authors: Lok, Kerry H, Benjamin, Jr, William H, Kimerling, Michael E, Pruitt, Virginia, Mulcahy, Donna, Robinson, Nancy, Keenan, Nancy B, Dunlap, Nancy E
Format: Article
Language:English
Subjects:
Alabama - epidemiology
Bacterial Typing Techniques
Control
Dispatch
DNA Fingerprinting
Drug Resistance, Bacterial
Genetic aspects
Genetic Variation
Health aspects
homeless
Humans
Infection
Molecular Epidemiology
Mycobacteria
Mycobacterium tuberculosis - classification
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Prevention
spoligotype
Tuberculosis
tuberculosis (TB) genotyping
Tuberculosis - epidemiology
Tuberculosis - microbiology
United States
variable number of tandem repeats (VNTR)
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Summary:We conducted a program of population-based molecular typing of all Mycobacterium tuberculosis isolates obtained in Alabama since 1994. Of 2452 isolates, 1013 (41%) had fewer than 6 bands of IS6110; 348 (14%) had a single two-band pattern (JH2). With conventional epidemiologic methods, we identified three groups of related patients with JH2 isolates. Spoligotyping and pattern of variable number of tandem repeats identified 10 molecular groups; two found by conventional methods were subdivided.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid0811.020292