Correlation of dermal and blood eosinophilia with bullous pemphigoid disease severity

• Published in: International journal of women's dermatology 2020-06, Vol.6 (3), p.171-175
• Main Authors: Farnaghi, Farshad, Ehsani, Amir-hooshang, Kamyab-Hesary, Kambiz, Abbasian, Sepideh, Seirafi, Hasan, Nasimi, Maryam
• Format: Article
• Language: English
• Subjects: Anti-BP-180; Anti-BP-230; Bullous pemphigoid; Dermal eosinophils; Peripheral blood eosinophilia
• ISSN: 2352-6475; 2352-6475
• DOI: 10.1016/j.ijwd.2020.01.005

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease associated with immune response against BP-180 and BP-230. Peripheral blood eosinophilia and dermal infiltration of eosinophils are common findings in BP. The aim of our study was to demonstrate a statistical correlation between dermal and peripheral blood eosinophilia, anti BP-180, and anti BP-230 IgG and clinical severity of BP. A total of 27 patients with newly diagnosed BP were included. Severity of disease was assessed according to the bullous pemphigoid disease activity index (BPDAI). Anti-BP-180 and anti-BP-230 titers, peripheral blood eosinophilia, and dermal eosinophil infiltration and tissue inflammation severity were assessed for each patient. A significant correlation was found between the serum levels of anti-BP-180 and anti-BP-230, and dermal eosinophilia and tissue inflammation severity with objective and subjective BPDAI scores. In addition, there was a significant correlation between the percentage of peripheral blood eosinophils and subjective BPDAI scores and urticarial/eczematous lesions. Moreover, the mucosal component did not show any correlation with autoantibody levels and inflammation severities. Anti-BP-180 and anti-BP-230 levels, tissue inflammation severity, and dermal eosinophilia had a strong and significant correlation with BP severity. In addition, percentage of peripheral blood eosinophilia showed a correlation with subjective BPDAI scores.