Nanocellulose-Based Film-Forming Hydrogels for Improved Outcomes in Atopic Skin

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by impaired skin barrier function. Amongst the various dermal formulations that are being used and/or investigated for AD treatment, one of the advanced approaches is the use of hydrogels as film-forming systems that are app...

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Bibliographic Details
Published in:Pharmaceutics 2023-07, Vol.15 (7), p.1918
Main Authors: Bolko Seljak, Katarina, Sterle Zorec, Barbara, Gosenca Matjaž, Mirjam
Format: Article
Language:English
Subjects:
Acids
Advertising executives
Atopic dermatitis
betamethasone dipropionate
Disease
Drug delivery systems
Drugs
film-forming hydrogels
Hydrogels
Microemulsions
nanocrystalline cellulose
Nanoparticles
Patient outcomes
Polyethylene glycol
Rheology
Skin
SMEDDS
Surfactants
Vehicles
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Summary:Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by impaired skin barrier function. Amongst the various dermal formulations that are being used and/or investigated for AD treatment, one of the advanced approaches is the use of hydrogels as film-forming systems that are applied directly to the skin and have the added value of providing a physical barrier, which is lacking in atopic skin. Novel film-forming hydrogels based on two different nanocrystalline celluloses (NCCs) in combination with one of two natural polymers (alginate or pectin) were developed for incorporation of betamethasone dipropionate (BDP). Initially, the low water solubility of BDP was resolved by prior dissolution in a self-microemulsifying drug delivery system (SMEDDS). The mixture of Kolliphor EL/Capryol 90 in a ratio of 8/2 was chosen on the merit of its high BDP-saturated solubility and no BDP precipitation upon water dilution, enabling BDP to remain dissolved after incorporation into hydrogels. The solvent evaporation method was used to prepare the films, and their high water retention capacity was confirmed in vitro on artificial membranes and pig ear skin. The presented results thus confirm NCC-based film-forming hydrogels as a very promising drug delivery system for AD treatment.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15071918