Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by a progressive loss of visual function that primarily affect photoreceptors, resulting in the complete disorganization and remodeling of the retina. Progression of the disease is enhanced by increased oxidat...

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Bibliographic Details
Published in:Antioxidants 2021-11, Vol.10 (11), p.1853
Main Authors: Fuentes-Broto, Lorena, Perdices, Lorena, Segura, Francisco, Orduna-Hospital, Elvira, Insa-Sánchez, Gema, Sánchez-Cano, Ana I., Cuenca, Nicolás, Pinilla, Isabel
Format: Article
Language:English
Subjects:
Age
Animal models
Animals
antioxidant
Antioxidants
Circadian rhythm
Circadian rhythms
Diabetes mellitus
Drinking water
Ethanol
Free radicals
Glaucoma
Liver
Macular degeneration
Melatonin
Neurodegeneration
Neurodegenerative diseases
Oxidative stress
Photoreceptors
Proteins
Retina
Retinitis
Retinitis pigmentosa
Retinopathy
Software
Supplements
Synchronization
Visual perception
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Summary:Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by a progressive loss of visual function that primarily affect photoreceptors, resulting in the complete disorganization and remodeling of the retina. Progression of the disease is enhanced by increased oxidative stress in the retina, aqueous humor, plasma, and liver of RP animal models and patients. Melatonin has beneficial effects against age-related macular degeneration, glaucoma, and diabetic retinopathy, in which oxidative stress plays a key role. In the present study, we used the P23HxLE rat as an animal model of RP. Melatonin treatment (10 mg/kg b.w. daily in drinking water for 6 months) improved the parameters of visual function and decreased the rate of desynchronization of the circadian rhythm, both in P23HxLE and wild-type rats. Melatonin reduced oxidative stress and increased antioxidant defenses in P23HxLE animals. In wild-type animals, melatonin did not modify any of the oxidative stress markers analyzed and reduced the levels of total antioxidant defenses. Treatment with melatonin improved visual function, circadian synchronization, and hepatic oxidative stress in P23HxLE rats, an RP model, and had beneficial effects against age-related visual damage in wild-type rats.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10111853