Pretreatment and treatment with fructo-oligosaccharides attenuate intestinal mucositis induced by 5-FU in mice

[Display omitted] Mucositis is a side effect observed in patients undergoing chemotherapy. Besides, this treatment also leads to the imbalance of the intestinal microbiota. This study evaluated the effects of pre and treatment with fructo-oligosaccharides (FOS) in intestinal mucositis induced by 5-f...

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Published in:Journal of functional foods 2018-10, Vol.49, p.485-492
Main Authors: Galdino, Flávia Mendes Peradeles, Andrade, Maria Emília Rabelo, Barros, Patrícia Aparecida Vieira de, Generoso, Simone de Vasconcelos, Alvarez-Leite, Jacqueline Isaura, Almeida-Leite, Camila Megale de, Peluzio, Maria do Carmo Gouveia, Fernandes, Simone Odília Antunes, Cardoso, Valbert Nascimento
Format: Article
Language:English
Subjects:
5-fluorouracil
Fructo-oligosaccharides
Intestinal permeability
Mucositis
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Summary:[Display omitted] Mucositis is a side effect observed in patients undergoing chemotherapy. Besides, this treatment also leads to the imbalance of the intestinal microbiota. This study evaluated the effects of pre and treatment with fructo-oligosaccharides (FOS) in intestinal mucositis induced by 5-fluorouracil (5-FU). Balb/c mice were divided into four groups: CTL (without mucositis + saline), MUC (mucositis + saline), PT (mucositis + 6% FOS before disease induction) and T (mucositis + 6% FOS after disease induction). Mucositis was induced with an intraperitoneal injection of 300 mg/kg 5-FU. After 72 h intestinal permeability (IP), inflammatory infiltrate, oxidative stress, histological analysis, and short-chain fatty acids (SCFA) production were evaluated. The MUC group showed lost weight, intense inflammatory infiltrate, increased oxidative stress and IP (P 
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2018.09.012