Corticosteroid Pulses for Hospitalized Patients with COVID-19: Effects on Mortality

Objectives. To assess the influence of corticosteroid pulses on 60-day mortality in hospitalized patients with severe COVID-19. Methods. We designed a multicenter retrospective cohort study in three teaching hospitals of Castilla y León, Spain (865,096 people). We selected patients with confirmed CO...

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Bibliographic Details
Published in:Mediators of inflammation 2021, Vol.2021, p.6637227-10
Main Authors: Cusacovich, Ivan, Aparisi, Álvaro, Marcos, Miguel, Ybarra-Falcón, Cristina, Iglesias-Echevarria, Carolina, Lopez-Veloso, Maria, Barraza-Vengoechea, Julio, Dueñas, Carlos, Juarros Martínez, Santiago Antonio, Rodríguez-Alonso, Beatriz, Martín-Oterino, José-Ángel, Montero-Baladia, Miguel, Moralejo, Leticia, Andaluz-Ojeda, David, Gonzalez-Fuentes, Roberto
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Aged
Aged, 80 and over
Analysis
Coronaviruses
Corticosteroids
COVID-19
COVID-19 - mortality
COVID-19 Drug Treatment
Drug dosages
Female
Hospital patients
Hospitalization
Humans
Immunosuppressive Agents - therapeutic use
Inpatients
Male
Methylprednisolone
Middle Aged
Mortality
Patient outcomes
Patients
Propensity Score
Proportional Hazards Models
Retrospective Studies
Spain
Spain - epidemiology
Treatment Outcome
United Kingdom
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Summary:Objectives. To assess the influence of corticosteroid pulses on 60-day mortality in hospitalized patients with severe COVID-19. Methods. We designed a multicenter retrospective cohort study in three teaching hospitals of Castilla y León, Spain (865,096 people). We selected patients with confirmed COVID-19 and lung involvement with a pO2/FiO2
ISSN:0962-9351
1466-1861
1466-1861
DOI:10.1155/2021/6637227