Clinical Characteristics and Management Strategies for Adult Obese Asthma Patients

The rates of asthma and obesity are increasing concurrently in the United States. Epidemiologic studies demonstrate that the incidence of asthma increases with obesity. Furthermore, obese individuals have asthma that is more severe, harder to control, and resistant to standard medications. In fact,...

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Bibliographic Details
Published in:Journal of asthma and allergy 2022-01, Vol.15, p.673-689
Main Authors: Farzan, Sherry, Coyle, Tyrone, Coscia, Gina, Rebaza, Andre, Santiago, Maria
Format: Article
Language:English
Subjects:
Adults
Asthma
bmi
body mass index
Obesity
Respiratory agents
Review
Strategic planning (Business)
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Summary:The rates of asthma and obesity are increasing concurrently in the United States. Epidemiologic studies demonstrate that the incidence of asthma increases with obesity. Furthermore, obese individuals have asthma that is more severe, harder to control, and resistant to standard medications. In fact, specific asthma-obesity phenotypes have been identified. Various pathophysiologic mechanisms, including mechanical, inflammatory, metabolic and microbiome-associated, are at play in promulgating the obese-asthma phenotypes. While standard asthma medications, such as inhaled corticosteroids and biologics, are currently used to treat obese asthmatics, they may have limited effectiveness. Targeting the underlying aberrant processes, such as addressing steroid resistance, microbiome, metabolic and weight loss approaches, may be helpful.
ISSN:1178-6965
1178-6965
DOI:10.2147/JAA.S285738