Homocysteine Metabolism in Children with Idiopathic Nephrotic Syndrome

• Published in: Clinical and translational science 2014-04, Vol.7 (2), p.132-136
• Main Authors: Kundal, Mohan, Saha, Abhijeet, Dubey, N.K., Kapoor, Kanika, Basak, Trayambak, Bhardwaj, Gaurav, Tanwar, Vinay Singh, Sengupta, Shantanu, Batra, Vinita, Upadhayay, Ashish Dutt, Bhatt, Ajay
• Format: Article
• Language: English
• Subjects: Acids; Arteriosclerosis; Binding sites; Blood pressure; Case-Control Studies; Chemical bonds; Child; Children; Cholesterol - blood; Communication; Competition; Cysteine; Cysteine - blood; Cysteine - urine; Demography; Female; Folic acid; Folic Acid - blood; Health risk assessment; High-performance liquid chromatography; Homocysteine; Homocysteine - blood; Homocysteine - metabolism; Humans; Hyperhomocysteinemia; Hypertension; Kidney diseases; Male; Metabolism; Nephrotic syndrome; Nephrotic Syndrome - blood; Nephrotic Syndrome - metabolism; Nephrotic Syndrome - urine; Pediatrics; Plasma levels; Population; Potassium; Proteins; Proteinuria - blood; Remission; Remission Induction; Risk factors; Serum Albumin - metabolism; Standard deviation; Statistical analysis; Studies; Thrombosis; Urine; Vitamin B; Vitamin B 12 - blood; Vitamin B12
• ISSN: 1752-8054; 1752-8062
• DOI: 10.1111/cts.12145

Background Homocysteine metabolism is altered in children with idiopathic nephrotic syndrome. Hyperhomocysteinemia is a risk factor of early atherosclerosis and glomerulosclerosis and may occur at time of first occurrence of idiopathic nephrotic syndrome. Methods Thirty children with first episode of idiopathic nephrotic syndrome (FENS) aged 1–16 years along with 30 age‐ and sex‐matched healthy controls were enrolled in this study. Homocysteine and cysteine were measured with HPLC; vitamin B12 and folic acid were measured with electro‐chemilumiscence immunoassay. Primary outcome measure was plasma homocysteine level in children with FENS and in controls. Secondary outcome measures were (1) plasma and urine homocysteine and cysteine levels in children with FENS at 12 weeks and 1 year (remission) and (2) plasma and urine levels of vitamin B12 and folic acid in children with FENS, at 12 weeks and 1 year (remission). Results Plasma homocysteine and cysteine levels were comparable to controls in children with FENS, at 12 weeks and 1‐year remission. Plasma levels of vitamin B12 and folic acid were significantly decreased compared to controls in FENS due to increased urinary excretion, which normalize during remission at 12 weeks and 1 year. Urinary homocysteine and cysteine levels were significantly raised in FENS compared to controls and continued to be raised even at 12‐week and 1‐year remission. Conclusion Homocysteine metabolism is deranged in children with FENS. Renal effects of long‐term raised urinary homocysteine levels need to be studied.