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Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Family: Novel Prognostic Biomarkers and Tumor Microenvironment Regulators for Lower-Grade Glioma
Lower-grade glioma (LGG) is a group of tumors arising from the cells of the central nervous system. Although various therapy interventions are used, the prognosis remains different. Novel biomarkers are needed for the prognosis of disease and novel therapeutic strategies in LGG. The procollagen-lysi...
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Published in: | Frontiers in cellular neuroscience 2022-02, Vol.16, p.838548-838548 |
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description | Lower-grade glioma (LGG) is a group of tumors arising from the cells of the central nervous system. Although various therapy interventions are used, the prognosis remains different. Novel biomarkers are needed for the prognosis of disease and novel therapeutic strategies in LGG. The procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) family contains three members and is related to multiple cancers, yet it was not investigated in LGG. Data from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) cohorts were used to analyze the role of PLOD in LGG. As the PLOD family is involved in processes, such as tumor formation and cancer metastasis, we focused on its relationship to the tumor microenvironment (TME) in LGG. A high expression of the PLOD family relates to poor prognosis and high infiltration of immune cells within the TME. The expression level of the PLOD family might become a novel biomarker for prognosis and is a potential target for individual treatment decisions in LGG. |
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Although various therapy interventions are used, the prognosis remains different. Novel biomarkers are needed for the prognosis of disease and novel therapeutic strategies in LGG. The procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) family contains three members and is related to multiple cancers, yet it was not investigated in LGG. Data from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) cohorts were used to analyze the role of PLOD in LGG. As the PLOD family is involved in processes, such as tumor formation and cancer metastasis, we focused on its relationship to the tumor microenvironment (TME) in LGG. A high expression of the PLOD family relates to poor prognosis and high infiltration of immune cells within the TME. The expression level of the PLOD family might become a novel biomarker for prognosis and is a potential target for individual treatment decisions in LGG.</description><identifier>ISSN: 1662-5102</identifier><identifier>EISSN: 1662-5102</identifier><identifier>DOI: 10.3389/fncel.2022.838548</identifier><identifier>PMID: 35250490</identifier><language>eng</language><publisher>Switzerland: Frontiers Research Foundation</publisher><subject>Biomarkers ; Brain tumors ; Cancer ; Cellular Neuroscience ; Central nervous system ; Collagen ; Datasets ; Disease ; Gene expression ; Genomes ; Glioma ; immune infiltration ; Immunology ; immunotherapy ; Ketoglutaric acid ; lower-grade glioma ; Lysine ; Medical prognosis ; Metastases ; Patients ; PLOD family ; Procollagen ; Procollagen-lysine 5-dioxygenase ; Prognosis ; Proteins ; Software ; Survival analysis ; Tumor microenvironment</subject><ispartof>Frontiers in cellular neuroscience, 2022-02, Vol.16, p.838548-838548</ispartof><rights>Copyright © 2022 Gong, Wu, Köhler, Meixensberger, Schopow and Kallendrusch.</rights><rights>2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022 Gong, Wu, Köhler, Meixensberger, Schopow and Kallendrusch. 2022 Gong, Wu, Köhler, Meixensberger, Schopow and Kallendrusch</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-484822cf0983c6fcd9811de1d99312e8b0694308ad1e0366eb758b3d0f21380d3</citedby><cites>FETCH-LOGICAL-c493t-484822cf0983c6fcd9811de1d99312e8b0694308ad1e0366eb758b3d0f21380d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894330/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894330/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35250490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gong, Siming</creatorcontrib><creatorcontrib>Wu, Changwu</creatorcontrib><creatorcontrib>Köhler, Franziska</creatorcontrib><creatorcontrib>Meixensberger, Jürgen</creatorcontrib><creatorcontrib>Schopow, Nikolas</creatorcontrib><creatorcontrib>Kallendrusch, Sonja</creatorcontrib><title>Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Family: Novel Prognostic Biomarkers and Tumor Microenvironment Regulators for Lower-Grade Glioma</title><title>Frontiers in cellular neuroscience</title><addtitle>Front Cell Neurosci</addtitle><description>Lower-grade glioma (LGG) is a group of tumors arising from the cells of the central nervous system. Although various therapy interventions are used, the prognosis remains different. Novel biomarkers are needed for the prognosis of disease and novel therapeutic strategies in LGG. The procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) family contains three members and is related to multiple cancers, yet it was not investigated in LGG. Data from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) cohorts were used to analyze the role of PLOD in LGG. As the PLOD family is involved in processes, such as tumor formation and cancer metastasis, we focused on its relationship to the tumor microenvironment (TME) in LGG. A high expression of the PLOD family relates to poor prognosis and high infiltration of immune cells within the TME. The expression level of the PLOD family might become a novel biomarker for prognosis and is a potential target for individual treatment decisions in LGG.</description><subject>Biomarkers</subject><subject>Brain tumors</subject><subject>Cancer</subject><subject>Cellular Neuroscience</subject><subject>Central nervous system</subject><subject>Collagen</subject><subject>Datasets</subject><subject>Disease</subject><subject>Gene expression</subject><subject>Genomes</subject><subject>Glioma</subject><subject>immune infiltration</subject><subject>Immunology</subject><subject>immunotherapy</subject><subject>Ketoglutaric acid</subject><subject>lower-grade glioma</subject><subject>Lysine</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Patients</subject><subject>PLOD family</subject><subject>Procollagen</subject><subject>Procollagen-lysine 5-dioxygenase</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Software</subject><subject>Survival analysis</subject><subject>Tumor microenvironment</subject><issn>1662-5102</issn><issn>1662-5102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdks1u1DAUhSMEoqXwAGyQJTYsyOCfxLFZVIJCh0oDRaisLSe-CR4cu9jJ0HkM3hhPp1QtK1u-53469_oUxXOCF4wJ-ab3HbgFxZQuBBN1JR4Uh4RzWtYE04d37gfFk5TWGHPKK_G4OGA1rXEl8WHx52sMXXBOD-DL1TZZD68RLc-vwuDmSUc9AarLDzZcbbNCJ0CnerRu-xZ9CRtwKLcPPqTJdui9DaOOPyEmpL1BF_MYIvpsuxjAb2wMfgQ_oW8wzE5PIav6XF-F3xDLZdQG0NLtCE-LR712CZ7dnEfF99OPFyefytX58uzk3arsKsmmshKVoLTrsRSs431npCDEADFSMkJBtJjLimGhDQHMOIe2qUXLDO4pYQIbdlSc7bkm6LW6jDab36qgrbp-CHFQOua5HKieEFa3GtfUtBXIpm1A1rLnXGAmSSMz63jPupzbEUyXB43a3YPer3j7Qw1ho4TIJhnOgFc3gBh-zZAmNdqUP9dpD2FOinLGhWgaXmfpy_-k6zBHn1e1U-GKMFbtHJG9Kq8_pQj9rRmC1S486jo8ahcetQ9P7nlxd4rbjn9pYX8B8wLCaw</recordid><startdate>20220218</startdate><enddate>20220218</enddate><creator>Gong, Siming</creator><creator>Wu, Changwu</creator><creator>Köhler, Franziska</creator><creator>Meixensberger, Jürgen</creator><creator>Schopow, Nikolas</creator><creator>Kallendrusch, Sonja</creator><general>Frontiers Research Foundation</general><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20220218</creationdate><title>Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Family: Novel Prognostic Biomarkers and Tumor Microenvironment Regulators for Lower-Grade Glioma</title><author>Gong, Siming ; 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Although various therapy interventions are used, the prognosis remains different. Novel biomarkers are needed for the prognosis of disease and novel therapeutic strategies in LGG. The procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) family contains three members and is related to multiple cancers, yet it was not investigated in LGG. Data from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) cohorts were used to analyze the role of PLOD in LGG. As the PLOD family is involved in processes, such as tumor formation and cancer metastasis, we focused on its relationship to the tumor microenvironment (TME) in LGG. A high expression of the PLOD family relates to poor prognosis and high infiltration of immune cells within the TME. The expression level of the PLOD family might become a novel biomarker for prognosis and is a potential target for individual treatment decisions in LGG.</abstract><cop>Switzerland</cop><pub>Frontiers Research Foundation</pub><pmid>35250490</pmid><doi>10.3389/fncel.2022.838548</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Biomarkers Brain tumors Cancer Cellular Neuroscience Central nervous system Collagen Datasets Disease Gene expression Genomes Glioma immune infiltration Immunology immunotherapy Ketoglutaric acid lower-grade glioma Lysine Medical prognosis Metastases Patients PLOD family Procollagen Procollagen-lysine 5-dioxygenase Prognosis Proteins Software Survival analysis Tumor microenvironment |
title | Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Family: Novel Prognostic Biomarkers and Tumor Microenvironment Regulators for Lower-Grade Glioma |
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