Potential Biomarkers of Peripheral and Central Fatigue in High-Intensity Trained Athletes at High-Temperature: A Pilot Study with Momordica charantia (Bitter Melon)

Among potent dietary supplements, Momordica charantia, commonly called bitter melon, has various biological effects, such as antioxidant and anti-inflammatory effects, and improves energy metabolism and fatigue recovery. However, it is unknown whether Momordica charantia extract (MCE) induces antifa...

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Bibliographic Details
Published in:Journal of immunology research 2020, Vol.2020 (2020), p.1-11
Main Authors: Kwak, Jae-Jun, Ha, Min-Seong, Yook, Jang Soo
Format: Article
Language:English
Subjects:
Adult
Ammonia
Antioxidants
Athletes
Biomarkers
Dietary Supplements
Dopamine
Drug dosages
Energy
Energy metabolism
Exercise
Experiments
Fatigue
Fatigue - diagnosis
Fatigue - etiology
Fatigue - metabolism
Female
Food
Heart rate
Heat
Hot Temperature
Humans
Immunology
Inflammation
Kinases
Male
Medical research
Metabolism
Metabolites
Momordica charantia
Momordica charantia - chemistry
Nutrition
Physical fitness
Physical training
Physiology
Pilot Projects
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Prolactin
Researchers
Seasons
Serotonin
Standard deviation
Studies
Teaching
Tennis
Uric acid
Weightlifting
Young Adult
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Summary:Among potent dietary supplements, Momordica charantia, commonly called bitter melon, has various biological effects, such as antioxidant and anti-inflammatory effects, and improves energy metabolism and fatigue recovery. However, it is unknown whether Momordica charantia extract (MCE) induces antifatigue effects during exercise training in high-temperature environments. This study aimed at investigating the efficacy of MCE by examining 10 male tennis players consuming 100 mL MCE/dose (6 times a day over 4 weeks) during the summer training season. Peripheral (ammonia and uric acid) and central (serotonin, dopamine, and prolactin) fatigue parameters were measured before and after MCE consumption; before, during, and after exercise; and the next morning. After consuming MCE supplements, ammonia levels were higher during and after exercise and recovered the next morning, whereas uric acid levels did not change at any time point. Serotonin levels were lower during exercise. Dopamine levels were higher, especially during exercise. Prolactin levels were lower at all time points, especially during and after exercise. Although high-intensity training in a hot environment causes accumulation of fatigue-related metabolites, our results indicate that 4 weeks of MCE intake positively influenced fatigue parameters, suggesting that MCE can efficiently combat fatigue.
ISSN:2314-8861
2314-7156
DOI:10.1155/2020/4768390