Efficacy of silicone sheet as a personalized barrier for preventing adhesion reformation after hysteroscopic adhesiolysis of intrauterine adhesions

Purpose To evaluate the efficacy of silicone sheet as a new type of barrier for preventing adhesion reformation following hysteroscopic adhesiolysis of intrauterine adhesions (IUAs). Methods Hysteroscopic adhesiolysis was performed for 36 patients with IUAs. The adhesion reformation rate was retrosp...

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Bibliographic Details
Published in:Reproductive medicine and biology 2019-10, Vol.18 (4), p.378-383
Main Authors: Azumaguchi, Atsushi, Henmi, Hirofumi, Saito, Tsuyoshi
Format: Article
Language:English
Subjects:
Acids
Adhesion
Adhesions
Care and treatment
Cellulose
Hospitals
Hysterectomy
hysteroscopic adhesiolysis
Infertility
intrauterine adhesions
Intrauterine devices
Investigations
IUD
Original
oxidized regenerated cellulose
Pregnancy
Silicones
Surgeons
Surgery
Uterus
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Summary:Purpose To evaluate the efficacy of silicone sheet as a new type of barrier for preventing adhesion reformation following hysteroscopic adhesiolysis of intrauterine adhesions (IUAs). Methods Hysteroscopic adhesiolysis was performed for 36 patients with IUAs. The adhesion reformation rate was retrospectively compared between 26 patients treated with silicone sheet (group 1) and 10 patients treated with an intrauterine device wrapped in oxidized regenerated cellulose as a barrier (group 2). For patients in group 1, a 1‐mm‐thick silicone sheet was cut to fit the size and shape of the individual uterine cavity as a personalized barrier. Results The size and shape of each silicone sheet used for patients in group 1 differed significantly. The adhesion reformation rate was significantly lower in group 1 (4/26, 15.4%) than in group 2 (4/10, 40.0%; P = 0.03), although the pregnancy rate (14/20, 70.0% vs. 5/10, 50.0%; P = 0.28) and miscarriage rate (2/14, 14.3% vs. 1/5, 20.0%; P = 0.72) were not significantly different. Conclusion Use of silicone sheets appears to be effective for preventing adhesion reformation following hysteroscopic adhesiolysis of IUAs. This is the first study to investigate the efficacy of silicone sheet used as a personalized barrier for preventing IUAs. Silicone sheet could be easily cut to fit the size and shape of the individual uterine cavity as a personalized barrier. The adhesion reformation rate was significantly lower in patients treated with silicone sheet than in patients treated with oxidized regenerated cellulose and comparable to lowest adhesion reformation rate in recent 10 years reports.
ISSN:1445-5781
1447-0578
DOI:10.1002/rmb2.12294