Neutrophil gelatinase-associated lipocalin as a biomarker for predicting acute kidney injury after coronary artery bypass grafting

Background Early and precocious determination of acute kidney injury (AKI) is essential to prevent morbidity and mortality following coronary artery bypass grafting (CABG). Evaluation of the perioperative renal function is substantial using novel biomarkers other than the late traditional method of...

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Published in:Ain-Shams journal of anesthesiology 2021-01, Vol.13 (1), p.1-9, Article 5
Main Authors: Othman, Haitham Mohy El Din Mahmoud, Hassan, Alaa Eid Mohamed, Elsersi, Mayar Hassan, Soliman, Ahmed Kamal Mohamed Ali, Emam, Dalia Fahmy
Format: Article
Language:English
Subjects:
Acute kidney injury
Biomarkers
Cardiac surgery
Coronary vessels
Creatinine
Critical Care Medicine
Heart surgery
Intensive
Kidneys
Medicine
Medicine & Public Health
Neutrophil gelatinase-associated lipocalin
Neutrophils
Original
Original Article
Plasma
Serum creatinine
Surgery
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Summary:Background Early and precocious determination of acute kidney injury (AKI) is essential to prevent morbidity and mortality following coronary artery bypass grafting (CABG). Evaluation of the perioperative renal function is substantial using novel biomarkers other than the late traditional method of using serum creatinine. Plasma neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker investigated for early detection of AKI in patients undergoing coronary artery bypass grafting, and its role has to be determined in this study. Results Twenty-five patients undergoing elective CABG were enrolled in this cohort study and were assigned into two groups: group I include the patients that did not develop AKI (no AKI group) and group II include the patients that developed AKI (AKI group). Acute kidney injury based on Kidney Disease: Improving Global Outcomes (KDIGO) classification had been developed in 7 patients (28%). Plasma NGAL levels at 6 h were higher in patients who developed AKI compared with those who did not (302 ± 88.02 vs. 116.50 ± 17.33 ng/m, p value < 0.001). The cut-off value of plasma NGAL levels measured 6 h postoperatively was 145 ng/ml and the area under the receiver-operating characteristic (ROC) curve was 0.965. Results of this study showed that plasma NGAL is a robust early biomarker of AKI, which preceded the rise in serum creatinine by many hours. Conclusion This study revealed that earlier diagnosis of acute kidney injury in patients undergoing CABG can be achieved by measuring postoperative plasma NGAL concentration at 6 h.
ISSN:2090-925X
1687-7934
2090-925X
DOI:10.1186/s42077-020-00123-5