Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus Metapochonia lutea

In the process of screening for new bioactive microbial metabolites we found a novel ƴ-pyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-10, Vol.26 (21), p.6589
Main Authors: Labuda, Roman, Bacher, Markus, Gratzl, Hannes, Doppler, Maria, Parich, Alexandra, Aufy, Mohammed, Lemmens-Gruber, Rosa, Schuhmacher, Rainer, Rychli, Kathrin, Wagner, Martin, Rosenau, Thomas, Strauss, Joseph, Schüller, Christoph
Format: Article
Language:English
Subjects:
Acids
actinopyrones
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Carbon
Cell culture
Cell lines
Cytotoxicity
fungal metabolites
Fungi
Fungi - chemistry
Gram-negative bacteria
Gram-positive bacteria
High performance liquid chromatography
Hypocreales - chemistry
Liquid chromatography
Metabolites
Microorganisms
Molecular Structure
Sucrose
Verticillium-like species
verticipyrone
Yeast
Yeasts
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Summary:In the process of screening for new bioactive microbial metabolites we found a novel ƴ-pyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26216589