Discovering the interactome, functions, and clinical relevance of enhancer RNAs in kidney renal clear cell carcinoma

Enhancer RNA (eRNA) has emerged as a key player in cancer biology, influencing various aspects of tumor development and progression. In this study, we investigated the role of eRNAs in kidney renal clear cell carcinoma (KIRC), the most common subtype of renal cell carcinoma. Leveraging high-throughp...

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Bibliographic Details
Published in:BMC medical genomics 2025-01, Vol.18 (1), p.3-14, Article 3
Main Authors: Sun, Zhaohui, Du, Haojie, Zheng, Xudong, Zhang, Hepeng, Hu, Huajie
Format: Article
Language:English
Subjects:
Binding sites
Bioinformatics
Biomarkers
Carcinoma, Renal cell
Care and treatment
Cell cycle
Development and progression
E-P loops
ENSR00000305834
eRNA
Genes
Genetic aspects
Genomes
Glioma
Health aspects
Hypoxia
Immune response
Kidney cancer
KIRC
Liver cancer
Medical research
Next-generation sequencing
Peptides
Prediction models
Proteins
Regression analysis
Renal cell carcinoma
RNA
SLC15A2
Therapeutic targets
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Summary:Enhancer RNA (eRNA) has emerged as a key player in cancer biology, influencing various aspects of tumor development and progression. In this study, we investigated the role of eRNAs in kidney renal clear cell carcinoma (KIRC), the most common subtype of renal cell carcinoma. Leveraging high-throughput sequencing data and bioinformatics analysis, we identified differentially expressed eRNAs in KIRC and constructed eRNA-centric regulatory networks. Our findings revealed that up-regulated eRNAs in KIRC potentially regulate immune response and hypoxia pathways, while down-regulated eRNAs may impact ion transport, cell cycle, and metabolism. Furthermore, we developed a diagnostic prediction model based on eRNA expression profiles, demonstrating its effectiveness in KIRC diagnosis. Finally, we elucidated the regulatory mechanism of an eRNA (ENSR00000305834) on the expression of SLC15A2, a potential prognostic biomarker in KIRC, through bioinformatics analysis and in vitro validation experiments. In summary, Our study highlights the clinical significance of eRNAs in KIRC and underscores their potential as therapeutic targets.
ISSN:1755-8794
1755-8794
DOI:10.1186/s12920-024-02081-5