FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27 IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES

ABSTRACT Objective: To determine the frequency of Human leukocyte antigen B-27 patients with clinically diagnosed ankylosing spondylitis and frequency of peripheral joints' involvement and serum inflammatory markers (raised serum C-reactive protein and erythrocyte sedimentation rate). Study Des...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2019-12, Vol.69 (6), p.1194-1198
Main Authors: Sardar Muhammad, Fakhr, Amer, Manzar, Muhammad Adnan, Hakim, Farzana, Taimoor Ashraf Khan, Ahmad, Bilal
Format: Article
Language:English
Subjects:
Age groups
Ankylosing spondylitis
Antigens
Arthritis
axial spondylitis
Back pain
Classification
extra articular manifestation
HLA antigens
human leukocyte antigen b-27 (hla b-27)
Inflammation
inflammatory markers
Males
Patients
peripheral arthritis
Population
Proteins
Spondylitis
spondyloarthritis
Ultrasonic imaging
Uveitis
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Summary:ABSTRACT Objective: To determine the frequency of Human leukocyte antigen B-27 patients with clinically diagnosed ankylosing spondylitis and frequency of peripheral joints' involvement and serum inflammatory markers (raised serum C-reactive protein and erythrocyte sedimentation rate). Study Design: Descriptive, cross-sectional study. Place and Duration of Study: Department of Rheumatology Pak Emirates Military Hospital, Rawalpindi for duration of 10 months from Jan 2018 to Oct 2018. Methodology: We included 100 cases of Ankylosing Spondylitis. Sample was selected by consecutive sampling technique and used “(Modified) New York Classification Criteria for Ankylosing Spondylitis”. Blood samples for C-reactive protein and erythrocyte sedimentation rate and Human leukocyte antigen B-27 were analysed by the same pathologist. We analyzed the data by using SPSS version 20. Results: Mean age of cases was 25 ± 4.5 years. Seventy-seven patients were positive for Human leukocyte antigen B27 and 23 were negative. In 69% patients erythrocyte sedimentation rate was high and in 64% patients C-reactive protein was raised. In 33% patient there was only axial involvement while peripheral arthritis was present in 67% of patients and enthesitis in 60%. Only 5% patients have the uveitis (All positive for Human leukocyte antigen B-27). Only one patient had cardiac involvement. Conclusion: Ankylosing Spondylitis was found a common disease and study results showed similar trends of positive Human leukocyte antigen B-27 cases as in the rest of the world. Human leukocyte antigen B-27 has a strong statistically significant association with peripheral joint involvement and acute anterior uveitis.
ISSN:0030-9648
2411-8842