FgUbiH Is Essential for Vegetative Development, Energy Metabolism, and Antioxidant Activity in Fusarium graminearum

Fusarium head blight in wheat is mainly caused by and results in significant economic losses. Coenzyme Q (CoQ) is ubiquitously produced across organisms and functions as a hydrogen carrier in energy metabolism. While UbiH in serves as a hydroxylase in CoQ biosynthesis, its role in phytopathogenic fu...

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Bibliographic Details
Published in:Microorganisms (Basel) 2024-10, Vol.12 (10), p.2093
Main Authors: Ge, Jinwen, Zhai, Huanchen, Tang, Lei, Zhang, Shuaibing, Lv, Yangyong, Ma, Pingan, Wei, Shan, Zhou, Yu, Wu, Xiaofu, Lei, Yang, Zhao, Fengguang, Hu, Yuansen
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Aldehyde dehydrogenase
Aldehydes
Amino acids
Antioxidants
ATP
Biosynthesis
Carbohydrate metabolism
Carbohydrates
Cell death
Cloning
Coenzyme Q
Comparative analysis
Control
Deletion
Deletion mutant
deoxynivalenol
Development strategies
DNA methylation
E coli
Economic impact
Energy metabolism
Environmental aspects
Enzymes
Fusarium
Fusarium graminearum
Fusarium head blight
Genes
Genetic aspects
Germination
Growth
hydroxylase
Identification and classification
Metabolism
mitochondria
Oxidation
Pathogenicity
Pathogens
Pests
Physiological aspects
Phytopathogenic fungi
Plasmids
Polymerase chain reaction
Proteins
Reactive oxygen species
Toxins
Transcriptomes
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Summary:Fusarium head blight in wheat is mainly caused by and results in significant economic losses. Coenzyme Q (CoQ) is ubiquitously produced across organisms and functions as a hydrogen carrier in energy metabolism. While UbiH in serves as a hydroxylase in CoQ biosynthesis, its role in phytopathogenic fungi is not well understood. This study explored the role of the hydroxylase FgUbiH in . Using a deletion mutant, we observed reduced hyphal growth, conidial production, germination, toxin synthesis, and pathogenicity compared to the wild-type. A transcriptome analysis indicated 's involvement in regulating carbohydrate and amino acid metabolism. Deletion of impaired mitochondrial function, reducing adenosine triphosphate synthesis and increasing reactive oxygen species. Additionally, genes related to terpene skeleton synthesis and aldehyde dehydrogenase were downregulated. Our results underscore the importance of FgUbiH in 's growth, toxin production, and energy metabolism, aiding in the development of strategies for disease management.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms12102093