Zika virus reservoirs: Implications for transmission, future outbreaks, drug and vaccine development [version 1; peer review: 2 approved]

Zika virus (ZIKV) was recently declared as a 'Global Health Emergency' by the World Health Organization. Various tissue reservoirs of ZIKV in infected humans and animals models have been observed, the implications of which are not known. Compared to other Flaviviruses, sexual transmission...

Full description

Saved in:
Bibliographic Details
Published in:F1000 research 2017, Vol.6, p.1850-1850
Main Authors: Kalkeri, Raj, Murthy, Krishna K
Format: Article
Language:English
Subjects:
Animal models
Autophagy
Body fluids
Brain research
Dengue fever
Disease spread
Disease transmission
Encephalitis
Flavivirus
Fluids
Genitourinary tract
Immunization
Infections
Nervous system
Outbreaks
Parasitology
Placenta
Review
Saliva
Secretions
Semen
Sexual transmission
Studies
Transplants & implants
Tropical & Travel-Associated Diseases
Urine
Vaccine development
Vaccines
West Nile virus
Zika virus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Zika virus (ZIKV) was recently declared as a 'Global Health Emergency' by the World Health Organization. Various tissue reservoirs of ZIKV in infected humans and animals models have been observed, the implications of which are not known. Compared to other Flaviviruses, sexual transmission and persistence in the genitourinary tract seem to be unique to ZIKV. ZIKV persistence and shedding in bodily secretions (e.g. saliva, semen) is a concern for potential disease spread and could pose challenges in diagnosis, regulatory guidelines and drug/vaccine development. Murine and non-human primate models could be useful to study the role of tissue reservoirs in the development of prophylactic or therapeutic strategies. There is a need for meta-analysis of the ZIKV infection and virus shedding data from infected patients and ZIKV animal models, and additional research is needed to fully comprehend the long term implications of tissue reservoirs on ZIKV disease pathogenesis and biology.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.12695.1