Non-Platinum Metal Complexes as Potential Anti-Triple Negative Breast Cancer Agents

Breast cancer (BC) is the most common cancer in women worldwide, with a mortality rate that has been forecasted to rise in the next decade. This is especially worrying for people with triple-negative BC (TNBC), because of its unresponsiveness to current therapies. Different drugs to treat TNBC have...

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Bibliographic Details
Published in:Crystals (Basel) 2018-10, Vol.8 (10), p.369
Main Authors: Domínguez-Martís, Eva, Mosteiro-Miguéns, Diego, Vigo-Gendre, Lucía, López-Ares, David, Freire-Garabal, Manuel, Núñez-Iglesias, María, Novío, Silvia
Format: Article
Language:English
Subjects:
Anticancer properties
antiproliferative activity
Apoptosis
Breast cancer
Cancer
Cancer therapies
Cell cycle
Chemotherapy
Community health care
Coordination compounds
Cytotoxicity
Drugs
Medical prognosis
metal complexes
Metastasis
Mutation
Permeability
Platinum
Public health
Studies
treatment
triple negative breast cancer
Tumors
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Summary:Breast cancer (BC) is the most common cancer in women worldwide, with a mortality rate that has been forecasted to rise in the next decade. This is especially worrying for people with triple-negative BC (TNBC), because of its unresponsiveness to current therapies. Different drugs to treat TNBC have been assessed, and, although platinum chemotherapy drugs seem to offer some hope, their drawbacks have motivated extensive investigations into alternative metal-based BC therapies. This paper aims to: (i) describe the preliminary in vitro and in vivo anticancer properties of non-platinum metal-based complexes (NPMBC) against TNBC; and (ii) analyze the likely molecular targets involved in their anticancer activity.
ISSN:2073-4352
2073-4352
DOI:10.3390/cryst8100369