Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation : Does This Protect from Excessive Parenchymal Iron Loading?

Hepcidin is upregulated by inflammation and iron. Inherited (HFE genotype) and treatment-related factors (blood units (BU), Iron overload) affecting hepcidin (measured by C-ELISA) were studied in 42 consecutive patients with AML prior to and after allogeneic hematopoietic cell transplantation (HCT)....

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Bibliographic Details
Published in:Advances in hematology 2011, Vol.2011 (2011), p.1-8
Main Authors: Eisfeld, Ann-Kathrin, Westerman, Mark, Krahl, Rainer, Leiblein, Sabine, Liebert, Uwe Gerd, Hehme, Marianne, Teupser, Daniel, Niederwieser, Dietger, al-Ali, Haifa Kathrin
Format: Article
Language:English
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Summary:Hepcidin is upregulated by inflammation and iron. Inherited (HFE genotype) and treatment-related factors (blood units (BU), Iron overload) affecting hepcidin (measured by C-ELISA) were studied in 42 consecutive patients with AML prior to and after allogeneic hematopoietic cell transplantation (HCT). Results. Elevated serum ferritin pre- and post-HCT was present in all patients. Median hepcidin pre- and post-HCT of 358 and 398 ng/mL, respectively, were elevated compared to controls (median 52 ng/mL) (P
ISSN:1687-9104
1687-9112
DOI:10.1155/2011/491058