In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster ( Crassostrea gigas )

Pacific oyster ( ), an abundant bivalve consumed across the Pacific, is known to possess a wide range of bioactivities. While there has been some work on its bioactive hydrolysates, the discovery of bioactive peptides (BAPs) remains limited due to the resource-intensive nature of the existing discov...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-01, Vol.28 (2), p.651
Main Authors: Zhou, Leyi, Mendez, Rufa L, Kwon, Jung Yeon
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - metabolism
Antidiabetics
Antihypertensives
Antiinfectives and antibacterials
Antimicrobial agents
Binding sites
bioactive peptides
Bioavailability
Biocompatibility
Biological activity
Bitterness
Cancer
Case studies
Communication
Crassostrea - metabolism
Crassostrea gigas
Diabetes mellitus
Enzymes
Food
Functional foods & nutraceuticals
Hydrolysates
in silico prospecting
Inflammation
Intestine
Mollusks
oyster proteins
Oysters
Peptides
Peptides - metabolism
Peptides - pharmacology
Proteins
Seafood
Toxicity
Workflow
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Summary:Pacific oyster ( ), an abundant bivalve consumed across the Pacific, is known to possess a wide range of bioactivities. While there has been some work on its bioactive hydrolysates, the discovery of bioactive peptides (BAPs) remains limited due to the resource-intensive nature of the existing discovery pipeline. To overcome this constraint, in silico-based prospecting is employed to accelerate BAP discovery. Major oyster proteins were digested virtually under a simulated gastrointestinal condition to generate virtual peptide products that were screened against existing databases for peptide bioactivities, toxicity, bitterness, stability in the intestine and in the blood, and novelty. Five peptide candidates were shortlisted showing antidiabetic, anti-inflammatory, antihypertensive, antimicrobial, and anticancer potential. By employing this approach, oyster BAPs were identified at a faster rate, with a wider applicability reach. With the growing market for peptide-based nutraceuticals, this provides an efficient workflow for candidate scouting and end-use investigation for targeted functional product preparation.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28020651