Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66

Five new compounds named asperpenes A-C ( ⁻ ), 12,13-dedihydroversiol ( ), and methyl 6-oxo-3,6-dihydro-2 -pyran-4-carboxylate ( ), along with 10 known compounds ( ⁻ ), were isolated from the fermentation broth of sp. SCS-KFD66 associated with a bivalve mollusk, , collected from Haikou Bay, China. T...

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Bibliographic Details
Published in:Marine drugs 2018-11, Vol.16 (12), p.468
Main Authors: An, Chang-Liang, Kong, Fan-Dong, Ma, Qing-Yun, Xie, Qing-Yi, Yuan, Jing-Zhe, Zhou, Li-Man, Dai, Hao-Fu, Yu, Zhi-Fang, Zhao, You-Xing
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acids
antibacterial activity
Antimicrobial activity
Aspergillus
Aspergillus sp
Circular dichroism
Dichroism
E coli
Fermentation
Fungi
Glucosidase
Listeria
Listeria monocytogenes
Marine molluscs
marine-derived fungus
Mollusks
Natural products
Pathogens
R&D
Research & development
Sanguinolaria chinensis
Scavenging
secondary metabolites
Shellfish
Single crystals
Spectral analysis
Spectrum analysis
X-ray diffraction
X-ray diffraction analysis
α-Glucosidase
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Summary:Five new compounds named asperpenes A-C ( ⁻ ), 12,13-dedihydroversiol ( ), and methyl 6-oxo-3,6-dihydro-2 -pyran-4-carboxylate ( ), along with 10 known compounds ( ⁻ ), were isolated from the fermentation broth of sp. SCS-KFD66 associated with a bivalve mollusk, , collected from Haikou Bay, China. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were unambiguously determined by spectroscopic data, single-crystal X-ray diffraction analysis, and electronic circular dichroism (ECD) spectral analysis, along with quantum ECD calculations. The growth inhibitory activity of the compounds against four pathogenic bacterial ( ATCC 25922, ATCC 6538, ATCC 1911, and ATCC 6633), their enzyme inhibitory activities against acetylcholinesterase and α-glucosidase, and their DPPH radical scavenging activity were evaluated.
ISSN:1660-3397
1660-3397
DOI:10.3390/md16120468