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Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66
Five new compounds named asperpenes A-C ( ⁻ ), 12,13-dedihydroversiol ( ), and methyl 6-oxo-3,6-dihydro-2 -pyran-4-carboxylate ( ), along with 10 known compounds ( ⁻ ), were isolated from the fermentation broth of sp. SCS-KFD66 associated with a bivalve mollusk, , collected from Haikou Bay, China. T...
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| Published in: | Marine drugs 2018-11, Vol.16 (12), p.468 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c472t-271d4bdf650f3b7ee7568066c6a9a1871e6fe9e8f57c9f24b63e0bb88440cc403 |
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| cites | cdi_FETCH-LOGICAL-c472t-271d4bdf650f3b7ee7568066c6a9a1871e6fe9e8f57c9f24b63e0bb88440cc403 |
| container_end_page | |
| container_issue | 12 |
| container_start_page | 468 |
| container_title | Marine drugs |
| container_volume | 16 |
| creator | An, Chang-Liang Kong, Fan-Dong Ma, Qing-Yun Xie, Qing-Yi Yuan, Jing-Zhe Zhou, Li-Man Dai, Hao-Fu Yu, Zhi-Fang Zhao, You-Xing |
| description | Five new compounds named asperpenes A-C (
⁻
), 12,13-dedihydroversiol (
), and methyl 6-oxo-3,6-dihydro-2
-pyran-4-carboxylate (
), along with 10 known compounds (
⁻
), were isolated from the fermentation broth of
sp. SCS-KFD66 associated with a bivalve mollusk,
, collected from Haikou Bay, China. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were unambiguously determined by spectroscopic data, single-crystal X-ray diffraction analysis, and electronic circular dichroism (ECD) spectral analysis, along with quantum ECD calculations. The growth inhibitory activity of the compounds against four pathogenic bacterial (
ATCC 25922,
ATCC 6538,
ATCC 1911, and
ATCC 6633), their enzyme inhibitory activities against acetylcholinesterase and α-glucosidase, and their DPPH radical scavenging activity were evaluated. |
| doi_str_mv | 10.3390/md16120468 |
| format | article |
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⁻
), 12,13-dedihydroversiol (
), and methyl 6-oxo-3,6-dihydro-2
-pyran-4-carboxylate (
), along with 10 known compounds (
⁻
), were isolated from the fermentation broth of
sp. SCS-KFD66 associated with a bivalve mollusk,
, collected from Haikou Bay, China. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were unambiguously determined by spectroscopic data, single-crystal X-ray diffraction analysis, and electronic circular dichroism (ECD) spectral analysis, along with quantum ECD calculations. The growth inhibitory activity of the compounds against four pathogenic bacterial (
ATCC 25922,
ATCC 6538,
ATCC 1911, and
ATCC 6633), their enzyme inhibitory activities against acetylcholinesterase and α-glucosidase, and their DPPH radical scavenging activity were evaluated.</description><identifier>ISSN: 1660-3397</identifier><identifier>EISSN: 1660-3397</identifier><identifier>DOI: 10.3390/md16120468</identifier><identifier>PMID: 30486303</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acetylcholinesterase ; Acids ; antibacterial activity ; Antimicrobial activity ; Aspergillus ; Aspergillus sp ; Circular dichroism ; Dichroism ; E coli ; Fermentation ; Fungi ; Glucosidase ; Listeria ; Listeria monocytogenes ; Marine molluscs ; marine-derived fungus ; Mollusks ; Natural products ; Pathogens ; R&D ; Research & development ; Sanguinolaria chinensis ; Scavenging ; secondary metabolites ; Shellfish ; Single crystals ; Spectral analysis ; Spectrum analysis ; X-ray diffraction ; X-ray diffraction analysis ; α-Glucosidase</subject><ispartof>Marine drugs, 2018-11, Vol.16 (12), p.468</ispartof><rights>2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-271d4bdf650f3b7ee7568066c6a9a1871e6fe9e8f57c9f24b63e0bb88440cc403</citedby><cites>FETCH-LOGICAL-c472t-271d4bdf650f3b7ee7568066c6a9a1871e6fe9e8f57c9f24b63e0bb88440cc403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2582829517/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2582829517?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,36994,44571,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30486303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>An, Chang-Liang</creatorcontrib><creatorcontrib>Kong, Fan-Dong</creatorcontrib><creatorcontrib>Ma, Qing-Yun</creatorcontrib><creatorcontrib>Xie, Qing-Yi</creatorcontrib><creatorcontrib>Yuan, Jing-Zhe</creatorcontrib><creatorcontrib>Zhou, Li-Man</creatorcontrib><creatorcontrib>Dai, Hao-Fu</creatorcontrib><creatorcontrib>Yu, Zhi-Fang</creatorcontrib><creatorcontrib>Zhao, You-Xing</creatorcontrib><title>Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66</title><title>Marine drugs</title><addtitle>Mar Drugs</addtitle><description>Five new compounds named asperpenes A-C (
⁻
), 12,13-dedihydroversiol (
), and methyl 6-oxo-3,6-dihydro-2
-pyran-4-carboxylate (
), along with 10 known compounds (
⁻
), were isolated from the fermentation broth of
sp. SCS-KFD66 associated with a bivalve mollusk,
, collected from Haikou Bay, China. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were unambiguously determined by spectroscopic data, single-crystal X-ray diffraction analysis, and electronic circular dichroism (ECD) spectral analysis, along with quantum ECD calculations. The growth inhibitory activity of the compounds against four pathogenic bacterial (
ATCC 25922,
ATCC 6538,
ATCC 1911, and
ATCC 6633), their enzyme inhibitory activities against acetylcholinesterase and α-glucosidase, and their DPPH radical scavenging activity were evaluated.</description><subject>Acetylcholinesterase</subject><subject>Acids</subject><subject>antibacterial activity</subject><subject>Antimicrobial activity</subject><subject>Aspergillus</subject><subject>Aspergillus sp</subject><subject>Circular dichroism</subject><subject>Dichroism</subject><subject>E coli</subject><subject>Fermentation</subject><subject>Fungi</subject><subject>Glucosidase</subject><subject>Listeria</subject><subject>Listeria monocytogenes</subject><subject>Marine molluscs</subject><subject>marine-derived fungus</subject><subject>Mollusks</subject><subject>Natural products</subject><subject>Pathogens</subject><subject>R&D</subject><subject>Research & development</subject><subject>Sanguinolaria chinensis</subject><subject>Scavenging</subject><subject>secondary metabolites</subject><subject>Shellfish</subject><subject>Single crystals</subject><subject>Spectral analysis</subject><subject>Spectrum analysis</subject><subject>X-ray diffraction</subject><subject>X-ray diffraction analysis</subject><subject>α-Glucosidase</subject><issn>1660-3397</issn><issn>1660-3397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkcFu1DAQhi0EoqVw4QFQJC4VUoodO2PnglSlLFQs4lA4W44z3vUqiRc7qcTb42VLaTl5NP70zdg_Ia8ZveC8oe_HngGrqAD1hJwyAFrmtnz6oD4hL1LaUcpr1Yjn5IRToYBTfkrW7RZHb81QtGFKs58XnOZUBFfMWyy-mugnLK8w-lvsi9UybZZUXKY9xo0fhlyn_UVx096UX1ZXAC_JM2eGhK_uzjPyY_Xxe_u5XH_7dN1erksrZDWXlWS96HoHNXW8k4iyBkUBLJjGMCUZgsMGlaulbVwlOuBIu04pIai1gvIzcn309sHs9D760cRfOhiv_zRC3GgTZ28H1I5JxXprKuZ6YRUYk8cBSGc6aRRCdn04uvZLN2Jv8_OjGR5JH99Mfqs34VYDZ1A3MgvO7wQx_FwwzXr0yeIwmAnDknTFeFNnkh1mvf0P3YUlTvmrdFWrSlVNzQ7Cd0fKxpBSRHe_DKP6ELj-F3iG3zxc_x79mzD_DZnVpPg</recordid><startdate>20181126</startdate><enddate>20181126</enddate><creator>An, Chang-Liang</creator><creator>Kong, Fan-Dong</creator><creator>Ma, Qing-Yun</creator><creator>Xie, Qing-Yi</creator><creator>Yuan, Jing-Zhe</creator><creator>Zhou, Li-Man</creator><creator>Dai, Hao-Fu</creator><creator>Yu, Zhi-Fang</creator><creator>Zhao, You-Xing</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TN</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H95</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20181126</creationdate><title>Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66</title><author>An, Chang-Liang ; Kong, Fan-Dong ; Ma, Qing-Yun ; Xie, Qing-Yi ; Yuan, Jing-Zhe ; Zhou, Li-Man ; Dai, Hao-Fu ; Yu, Zhi-Fang ; Zhao, You-Xing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-271d4bdf650f3b7ee7568066c6a9a1871e6fe9e8f57c9f24b63e0bb88440cc403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acetylcholinesterase</topic><topic>Acids</topic><topic>antibacterial activity</topic><topic>Antimicrobial activity</topic><topic>Aspergillus</topic><topic>Aspergillus sp</topic><topic>Circular dichroism</topic><topic>Dichroism</topic><topic>E coli</topic><topic>Fermentation</topic><topic>Fungi</topic><topic>Glucosidase</topic><topic>Listeria</topic><topic>Listeria monocytogenes</topic><topic>Marine molluscs</topic><topic>marine-derived fungus</topic><topic>Mollusks</topic><topic>Natural products</topic><topic>Pathogens</topic><topic>R&D</topic><topic>Research & development</topic><topic>Sanguinolaria chinensis</topic><topic>Scavenging</topic><topic>secondary metabolites</topic><topic>Shellfish</topic><topic>Single crystals</topic><topic>Spectral analysis</topic><topic>Spectrum analysis</topic><topic>X-ray diffraction</topic><topic>X-ray diffraction analysis</topic><topic>α-Glucosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>An, Chang-Liang</creatorcontrib><creatorcontrib>Kong, Fan-Dong</creatorcontrib><creatorcontrib>Ma, Qing-Yun</creatorcontrib><creatorcontrib>Xie, Qing-Yi</creatorcontrib><creatorcontrib>Yuan, Jing-Zhe</creatorcontrib><creatorcontrib>Zhou, Li-Man</creatorcontrib><creatorcontrib>Dai, Hao-Fu</creatorcontrib><creatorcontrib>Yu, Zhi-Fang</creatorcontrib><creatorcontrib>Zhao, You-Xing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oceanic Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Marine drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>An, Chang-Liang</au><au>Kong, Fan-Dong</au><au>Ma, Qing-Yun</au><au>Xie, Qing-Yi</au><au>Yuan, Jing-Zhe</au><au>Zhou, Li-Man</au><au>Dai, Hao-Fu</au><au>Yu, Zhi-Fang</au><au>Zhao, You-Xing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66</atitle><jtitle>Marine drugs</jtitle><addtitle>Mar Drugs</addtitle><date>2018-11-26</date><risdate>2018</risdate><volume>16</volume><issue>12</issue><spage>468</spage><pages>468-</pages><issn>1660-3397</issn><eissn>1660-3397</eissn><abstract>Five new compounds named asperpenes A-C (
⁻
), 12,13-dedihydroversiol (
), and methyl 6-oxo-3,6-dihydro-2
-pyran-4-carboxylate (
), along with 10 known compounds (
⁻
), were isolated from the fermentation broth of
sp. SCS-KFD66 associated with a bivalve mollusk,
, collected from Haikou Bay, China. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were unambiguously determined by spectroscopic data, single-crystal X-ray diffraction analysis, and electronic circular dichroism (ECD) spectral analysis, along with quantum ECD calculations. The growth inhibitory activity of the compounds against four pathogenic bacterial (
ATCC 25922,
ATCC 6538,
ATCC 1911, and
ATCC 6633), their enzyme inhibitory activities against acetylcholinesterase and α-glucosidase, and their DPPH radical scavenging activity were evaluated.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30486303</pmid><doi>10.3390/md16120468</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1660-3397 |
| ispartof | Marine drugs, 2018-11, Vol.16 (12), p.468 |
| issn | 1660-3397 1660-3397 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_f1781dca21fd4c86aaee7667fab7a8e6 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Acetylcholinesterase Acids antibacterial activity Antimicrobial activity Aspergillus Aspergillus sp Circular dichroism Dichroism E coli Fermentation Fungi Glucosidase Listeria Listeria monocytogenes Marine molluscs marine-derived fungus Mollusks Natural products Pathogens R&D Research & development Sanguinolaria chinensis Scavenging secondary metabolites Shellfish Single crystals Spectral analysis Spectrum analysis X-ray diffraction X-ray diffraction analysis α-Glucosidase |
| title | Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66 |
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