Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice

Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockout of tyro...

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Bibliographic Details
Published in:Molecular brain 2021-11, Vol.14 (1), p.1-170, Article 170
Main Authors: Kashiwagi, Mitsuaki, Kanuka, Mika, Tanaka, Kaeko, Fujita, Masayo, Nakai, Ayaka, Tatsuzawa, Chika, Kobayashi, Kazuto, Ikeda, Kazutaka, Hayashi, Yu
Format: Article
Language:English
Subjects:
Ablation
Arousal
Dopamine
Dopamine receptors
EEG
Electroencephalography
Eye movements
Hydroxylase
Micro Report
Mouse
Neurons
Norepinephrine
NREM sleep
Phenols
REM sleep
Roles
Sleep
Sleep and wakefulness
Tyrosine
Tyrosine 3-monooxygenase
Vigilance
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Summary:Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockout of tyrosine hydroxylase and its specific rescue in noradrenergic and adrenergic neurons. We found that DD mice have reduced time spent in wakefulness. Unexpectedly, DD mice also exhibited a marked reduction in the time spent in rapid eye movement (REM) sleep. The electroencephalogram power spectrum of all vigilance states in DD mice were also affected. These results support the current understanding of the critical roles of the dopaminergic system in maintaining wakefulness and also implicate its previously unknown effects on REM sleep.
ISSN:1756-6606
1756-6606
DOI:10.1186/s13041-021-00879-3