Metabolic cooperation between cancer and non-cancerous stromal cells is pivotal in cancer progression

The way cancer cells adapt to microenvironment is crucial for the success of carcinogenesis, and metabolic fitness is essential for a cancer cell to survive and proliferate in a certain organ/tissue. The metabolic remodeling in a tumor niche is endured not only by cancer cells but also by non-cancer...

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Bibliographic Details
Published in:Tumor Biology 2018-02, Vol.40 (2), p.1010428318756203-1010428318756203
Main Authors: Lopes-Coelho, Filipa, Gouveia-Fernandes, Sofia, Serpa, Jacinta
Format: Article
Language:English
Subjects:
Adipocytes
Angiogenesis
Authorship
Biosynthesis
Cancer
Carcinogenesis
Chemokines
Chitinase
Cooperation
Cytokines
Fibroblasts
Fitness
Growth factors
Hypoxia
Inflammation
Ligands
Macrophages
Medical research
Metabolism
Metastases
Metastasis
Monocytes
Organic compounds
Physical fitness
Smooth muscle
Stromal cells
Tumor cells
Tumors
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Summary:The way cancer cells adapt to microenvironment is crucial for the success of carcinogenesis, and metabolic fitness is essential for a cancer cell to survive and proliferate in a certain organ/tissue. The metabolic remodeling in a tumor niche is endured not only by cancer cells but also by non-cancerous cells that share the same microenvironment. For this reason, tumor cells and stromal cells constitute a complex network of signal and organic compound transfer that supports cellular viability and proliferation. The intensive dual-address cooperation of all components of a tumor sustains disease progression and metastasis. Herein, we will detail the role of cancer-associated fibroblasts, cancer-associated adipocytes, and inflammatory cells, mainly monocytes/macrophages (tumor-associated macrophages), in the remodeling and metabolic adaptation of tumors.
ISSN:1010-4283
1423-0380
DOI:10.1177/1010428318756203