Extracellular Water to Total Body Water Ratio in Viral Liver Diseases: A Study Using Bioimpedance Analysis

To investigate the relationship between extracellular water to total body water ratio (ECW/TBW) in bioimpedance analysis (BIA) and clinical parameters in hepatitis viruses related to liver diseases. ECW/TBW was compared in patients with hepatitis B virus (HBV, = 85) and hepatitis C virus (HCV, = 440...

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Published in:Nutrients 2018-08, Vol.10 (8), p.1072
Main Authors: Nishikawa, Hiroki, Yoh, Kazunori, Enomoto, Hirayuki, Ishii, Noriko, Iwata, Yoshinori, Nakano, Chikage, Takata, Ryo, Nishimura, Takashi, Aizawa, Nobuhiro, Sakai, Yoshiyuki, Ikeda, Naoto, Hasegawa, Kunihiro, Takashima, Tomoyuki, Iijima, Hiroko, Nishiguchi, Shuhei
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alanine
Alanine transaminase
bioimpedance analysis
Biomarkers - blood
Body Composition
Body water
Body Water - metabolism
Electric Impedance
extracellular water
Female
Fluid Shifts
Hepatitis
Hepatitis B
Hepatitis B - blood
Hepatitis B - physiopathology
Hepatitis B - virology
hepatitis B virus
Hepatitis C
Hepatitis C - blood
Hepatitis C - physiopathology
Hepatitis C - virology
hepatitis C virus
Humans
Liver
Liver diseases
Male
Middle Aged
Multivariate analysis
Patients
Prothrombin
Retrospective Studies
Serum albumin
total body water
Viruses
Water-Electrolyte Balance
Water-Electrolyte Imbalance - blood
Water-Electrolyte Imbalance - physiopathology
Water-Electrolyte Imbalance - virology
Young Adult
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Summary:To investigate the relationship between extracellular water to total body water ratio (ECW/TBW) in bioimpedance analysis (BIA) and clinical parameters in hepatitis viruses related to liver diseases. ECW/TBW was compared in patients with hepatitis B virus (HBV, = 85) and hepatitis C virus (HCV, = 440) related liver diseases. We also examined factors linked to mild to severe overhydrated state (ECW/TBW ≥0.4). The median ECW/TBW in the HCV group was 0.388 (range, 0.365⁻0.433), while that in the HBV group was 0.381 (range, 0.363⁻0.425) ( < 0.0001). In all cases ( = 525), for predicting F3 or more, ECW/TBW yielded the area under the receiver operating characteristics (AUROC, 0.74912) and for predicting F4, ECW/TBW yielded the AUROC (0.75517). Multivariate analysis showed that age, prothrombin time, serum albumin, and alanine aminotransferase were significant factors linked to ECW/TBW ≥0.4. In patients with FIB-4 index
ISSN:2072-6643
2072-6643
DOI:10.3390/nu10081072