Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease

Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a pressing burden on our developed and consequently aging society. Misfolded protein aggregates are a critical aspect of several neurodegenerative diseases. Nevertheless, several questions remain unanswer...

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Bibliographic Details
Published in:Journal of immunology research 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Gelders, Géraldine, Van der Perren, Anke, Baekelandt, Veerle
Format: Article
Language:English
Subjects:
Adaptive immunity
Aggregates
Aging
alpha-Synuclein - immunology
Alzheimer's disease
Animals
Apoptosis
Brain
Cell death
Chemokines
Disease
Epidemiology
Etiology
Homeostasis
Humans
Immunology
Inflammation
Movement disorders
Neurochemistry
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - immunology
Neurogenic Inflammation
Neuroimaging
Neurons
Neurons - physiology
Neuropathology
Neurosciences
Parkinson Disease - immunology
Parkinson's disease
Pathogenesis
Protein folding
Proteostasis Deficiencies - immunology
Review
Rodents
Synuclein
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Summary:Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a pressing burden on our developed and consequently aging society. Misfolded protein aggregates are a critical aspect of several neurodegenerative diseases. Nevertheless, several questions remain unanswered regarding the role of misfolded protein aggregates and the cause of neuronal cell death. Recently, it has been postulated that neuroinflammatory processes might play a crucial role in the pathogenesis of PD. Numerous postmortem, brain imaging, epidemiological, and animal studies have documented the involvement of the innate and adaptive immunity in neurodegeneration. Whether these inflammatory processes are directly involved in the etiology of PD or represent secondary consequences of nigrostriatal pathway injury is the subject of intensive research. Immune alterations in response to extracellular α-synuclein may play a critical role in modulating Parkinson’s disease progression. In this review, we address the current concept of neuroinflammation and its involvement in PD-associated neurodegeneration.
ISSN:2314-8861
2314-7156
DOI:10.1155/2018/4784268