Self-Crosslinked Ellipsoidal Poly(Tannic Acid) Particles for Bio-Medical Applications

Self-crosslinking of Tannic acid (TA) was accomplished to obtain poly(tannic acid) ( (TA)) particles in single step, surfactant free media using sodium periodate (NaIO ) as an oxidizing agent. Almost monodisperse (TA) particles with 981 ± 76 nm sizes and -22 ± 4 mV zeta potential value with ellipsoi...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-04, Vol.26 (9), p.2429
Main Author: Sahiner, Nurettin
Format: Article
Language:English
Subjects:
Aluminum
antibacterial
Antibacterial activity
antioxidant
Antioxidants
Bacteria
bio-medicinal applications
Biodegradation
Blood coagulation
Chelation
Clotting
Crosslinking
Dilution
Drug delivery systems
Food
Fourier transforms
Gram-positive bacteria
Iron
Oxidation
Oxidizing agents
Phenols
polyphenolic microgel/nanogel
Scanning electron microscopy
self-crosslinked flavonoid
Sodium
Spectrum analysis
Surfactants
Tannic acid
tannic acid particles
Vitamin E
Zeta potential
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Summary:Self-crosslinking of Tannic acid (TA) was accomplished to obtain poly(tannic acid) ( (TA)) particles in single step, surfactant free media using sodium periodate (NaIO ) as an oxidizing agent. Almost monodisperse (TA) particles with 981 ± 76 nm sizes and -22 ± 4 mV zeta potential value with ellipsoidal shape was obtained. Only slight degradation of (TA) particles with 6.8 ± 0.2% was observed at pH 7.4 in PBS up to 15 days because of the irreversible covalent formation between TA units, suggesting that hydrolytic degradation is independent from the used amounts of oxidation agents. (TA) particles were found to be non-hemolytic up to 0.5 mg/mL concentration and found not to affect blood clotting mechanism up to 2 mg/mL concentration. Antioxidant activity of (TA) particles was investigated by total phenol content (TPC), ferric reducing antioxidant potential (FRAP), trolox equivalent antioxidant capacity (TEAC), total flavanoid content (TFC), and Fe (II) chelating activity. (TA) particles showed strong antioxidant capability in comparison to TA molecules, except FRAP assay. The antibacterial activity of (TA) particles was investigated by micro-dilution technique on as Gram‑negative and as Gram-positive bacteria and found that (TA) particles are more effective on with over 50% inhibition at 20 mg/mL concentration attained.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26092429