Everolimus-encapsulation in Pluronic P123 self-assembled micelles as drug delivery systems for drug-coated balloons

Drug-coated balloons (DCBs) are effective tools for cardiovascular interventions, ensuring uniform drug delivery to occluded arteries. This research investigates the potential of Pluronic P123 (P123), a micelle-forming polymer, to solubilize and release Everolimus (EVE) from DCBs. Furthermore, it se...

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Bibliographic Details
Published in:International journal of pharmaceutics: X 2024-06, Vol.7, p.100230, Article 100230
Main Authors: Akrami-Hasan-Kohal, Mohammad, Chouchou, Adrien, Blanquer, Sébastien, Sharkawi, Tahmer
Format: Article
Language:English
Subjects:
Cardiology and cardiovascular system
Chemical Sciences
Drug delivery
Drug-coated balloons
Everolimus
Excipient
Human health and pathology
Life Sciences
Micelles
Pharmaceutical sciences
Pluronic P123
Research Paper
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Summary:Drug-coated balloons (DCBs) are effective tools for cardiovascular interventions, ensuring uniform drug delivery to occluded arteries. This research investigates the potential of Pluronic P123 (P123), a micelle-forming polymer, to solubilize and release Everolimus (EVE) from DCBs. Furthermore, it seeks to understand how the ratio of P123 to EVE affects release rates and micelle formation under physiological conditions. We tested three P123 to EVE ratios: 90:10, 75:25, and 50:50. Microscopy revealed that increasing EVE proportions resulted in more uniform coatings. Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the successful incorporation of EVE into the P123 matrix without altering its chemical properties. Differential scanning calorimetry (DSC) studies showed that EVE incorporation affected the crystalline structure of P123, leading to more uniform coatings. In vitro release studies showed that all formulations had
ISSN:2590-1567
2590-1567
DOI:10.1016/j.ijpx.2024.100230