Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture...

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Bibliographic Details
Published in:Autopsy & case reports 2021, Vol.11
Main Author: Frederick Eyerer, Juli-Anne Gardner
Format: Article
Language:English
Subjects:
ANATOMY & MORPHOLOGY
Clinical Case Report
Cyclin D
Lymphoma, Malignant
Lymphoma, Mantle-Cell
PATHOLOGY
Splenic Rupture
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Summary:Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.
ISSN:2236-1960
2236-1960
DOI:10.4322/acr.2021.340