Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery

Chitosan (CS) microparticles loaded with dexamethasone were prepared by spray drying, followed by coating with a pH-dependent interpolymer complex based on poly(acrylic acid)/poly(vinyl pyrrolidone) using an water-in-oil emulsion technique. The aim of this research was to evaluate the influence of P...

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Published in:International journal of polymer science 2019-01, Vol.2019 (2019), p.1-9
Main Authors: Peniche, Carlos, Abraham, Gustavo A., Caracciolo, Pablo C., Nogueira, Antonio, López Hernández, Orestes D., Bada-Rivero, Nancy, García-Couce, Jomarien, Ramón Hernández, José A.
Format: Article
Language:English
Subjects:
Acids
Acrylic acid
Beads
Chitosan
Coating
Colon
Complex formation
Dexamethasone
Drug delivery systems
Drug dosages
Microparticles
Pharmaceutical sciences
Polymers
Small intestine
Sodium
Spray drying
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container_issue 2019
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container_title International journal of polymer science
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creator Peniche, Carlos
Abraham, Gustavo A.
Caracciolo, Pablo C.
Nogueira, Antonio
López Hernández, Orestes D.
Bada-Rivero, Nancy
García-Couce, Jomarien
Ramón Hernández, José A.
description Chitosan (CS) microparticles loaded with dexamethasone were prepared by spray drying, followed by coating with a pH-dependent interpolymer complex based on poly(acrylic acid)/poly(vinyl pyrrolidone) using an water-in-oil emulsion technique. The aim of this research was to evaluate the influence of PAA/PVP coating on the release of dexamethasone from loaded chitosan microparticles, in simulated gastric fluid (SGF, pH=1.2) and simulated intestinal fluid (SIF, pH=6.8). The release of dexamethasone from uncoated loaded CS microparticles was similar in both fluids, and almost complete release of the drug was achieved in 5 hours. In the coated loaded CS microparticles, the release of dexamethasone in SGF was reduced considerably, very close to zero, due to the interpolymer complex formation at low pH, demonstrating that this system applied as pH-dependent coating has a potential as a site-specific delivery system.
doi_str_mv 10.1155/2019/4204375
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subjects Acids
Acrylic acid
Beads
Chitosan
Coating
Colon
Complex formation
Dexamethasone
Drug delivery systems
Drug dosages
Microparticles
Pharmaceutical sciences
Polymers
Small intestine
Sodium
Spray drying
title Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
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