The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes

Tau is abundantly expressed in neurons, however previous reports and our recent study showed tau also exist in oligodendrocytes. Also the expression levels of tau are dramatical changed in hypomyelination model rat and in demyelination region of stroke model mice. The review demonstrate microtubule...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2022-10, Vol.10, p.950682-950682
Main Authors: Torii, Tomohiro, Miyasaka, Tomohiro, Misonou, Hiroaki
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
demyelination
myelin
myelination
oligodendrocyte
tau
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Summary:Tau is abundantly expressed in neurons, however previous reports and our recent study showed tau also exist in oligodendrocytes. Also the expression levels of tau are dramatical changed in hypomyelination model rat and in demyelination region of stroke model mice. The review demonstrate microtubule and its binding partner Tau might be necessary for oligodendrocyte function based on previous reports.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.950682