Comparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk

Appraisal of muscle mass is important when considering the serious consequences of sarcopenia in an aging society. However, the associations between sarcopenia and its clinical outcomes might vary according to the method applied in its diagnosis. We compared the relationships between cardiometabolic...

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Bibliographic Details
Published in:Scientific reports 2017-07, Vol.7 (1), p.6491-9, Article 6491
Main Authors: Kim, Tae Nyun, Park, Man Sik, Lee, Eun Joo, Chung, Hye Soo, Yoo, Hye Jin, Kang, Hyun Joo, Song, Wook, Baik, Sei Hyun, Choi, Kyung Mook
Format: Article
Language:English
Subjects:
13/21
692/163/2743/393
692/700/1421/2109
Computed tomography
Dual energy X-ray absorptiometry
Health risks
Humanities and Social Sciences
Metabolic disorders
Metabolic syndrome
multidisciplinary
Risk factors
Sarcopenia
Science
Science (multidisciplinary)
Skeletal muscle
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Summary:Appraisal of muscle mass is important when considering the serious consequences of sarcopenia in an aging society. However, the associations between sarcopenia and its clinical outcomes might vary according to the method applied in its diagnosis. We compared the relationships between cardiometabolic risk parameters and sarcopenia defined according to three different diagnostic methods using dual-energy X-ray absorptiometry (DXA) and computed tomography (CT). Appendicular skeletal muscle mass (ASM) adjusted by height squared and BMI (ASM/height 2 and ASM/BMI) measured using DXA and thigh muscle cross-sectional area (tmCSA) adjusted by weight (tmCSA/weight) measured using CT were used as indices of muscle mass. Sarcopenia was defined as two standard deviations below either the mean ASM/height 2 , ASM/BMI, or tmCSA/weight of a young reference group. ASM/BMI and tmCSA/weight showed a negative relationship with several components of metabolic syndrome and HOMA-IR, whereas ASM/height 2 was positively associated with theses cardiometabolic risk factors. Logistic regression analyses demonstrated that ASM/BMI-defined sarcopenia was significantly associated with increased HOMA-IR ( P  = 0.01) and prevalence of visceral obesity ( P  = 0.03) and metabolic syndrome ( P  = 0.025), while ASM/height 2 - and tmCSA/weight-defined sarcopenia were not. ASM/BMI-defined sarcopenia exhibits a closer relationship with cardiometabolic risk factors than does ASM/height 2 - or tmCSA/weight-defined sarcopenia.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-06831-7