Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp 2 )-H activation and C(sp 3 )-H amination

A rhodium(III)-catalyzed intramolecular oxidative annulation of -substituted -hydroxyacrylamides for the construction of indolizinones via sequential C(sp )-H activation and C(sp )-H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold form...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2019-02, Vol.15 (1), p.571-576
Main Authors: Song, Liangliang, Tian, Guilong, Van der Eycken, Johan, Van der Eycken, Erik V
Format: Article
Language:English
Subjects:
acrylamide
annulation
Chemistry
C–H activation
heterocycles
Laboratories
Letter
Natural products
Rhodium
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Summary:A rhodium(III)-catalyzed intramolecular oxidative annulation of -substituted -hydroxyacrylamides for the construction of indolizinones via sequential C(sp )-H activation and C(sp )-H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.15.52