Editorial: New Insights Into Adult Neurogenesis and Neurodegeneration: Challenges for Brain Repair

[...]the regeneration process in zebrafish after brain damage is completely different from that observed in mammals. [...]microglial cells regulate neuronal development in specialized microenvironments of the adult brain. Since recent evidence suggests that in adulthood microglia secretes factors wh...

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Bibliographic Details
Published in:Frontiers in neuroscience 2022-03, Vol.16, p.868876-868876
Main Authors: Morales-García, Jose A, Kaneko, Naoko, Herranz-Pérez, Vicente
Format: Article
Language:English
Subjects:
Aging
Alcohol
Alzheimer's disease
Amyotrophic lateral sclerosis
Biology
Brain damage
Brain injury
Brain research
Cell cycle
Conflicts of interest
Estrogens
Hippocampus
Mammals
Microenvironments
Microglia
Microglial cells
neural stem and progenitor cell
Neurobiology
Neurodegeneration
Neurodegenerative diseases
Neurogenesis
Neurons
Neuroscience
Neurosciences
Regeneration
Senescence
Stem cells
subgranular zone (SGZ)
subventricular zone (SVZ)
Therapeutic targets
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Description
Summary:[...]the regeneration process in zebrafish after brain damage is completely different from that observed in mammals. [...]microglial cells regulate neuronal development in specialized microenvironments of the adult brain. Since recent evidence suggests that in adulthood microglia secretes factors which modulate adult hippocampal neurogenesis, Chintamen et al. discuss how interactions between immune cells and developing neurons may be leveraged for pharmacological intervention and as a means to preserve adult neurogenesis. [...]Yu et al. in their mini review discuss several potential drug targets that focus on the neurovascular unit informing about novel vascular-targeted therapies for neurodegenerative disorders like Alzheimer, Parkinson and amyotrophic lateral sclerosis.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2022.868876