Non-alcoholic fatty liver disease is associated with decreased bone mineral density in upper Egyptian patients

Nonalcoholic fatty liver disease (NAFLD) has been linked with a number of extra hepatic diseases and could be a potential risk factor of decreasing bone mineral density. To determine whether Upper Egyptian patients with NAFLD are at risk of developing osteoporosis. Cross sectional study was done on...

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Bibliographic Details
Published in:Scientific reports 2023-03, Vol.13 (1), p.4353-4353, Article 4353
Main Authors: Hassan, Amro M., Haridy, Mustafa Ahmed, Shoaeir, Mohamed Z., Abdel-Aziz, Tarek M., Qura, Mohamed Khairy, Kenawy, Eglal M., Mansour, Tarek Mohamed M., Salaheldin Elsayed, Sameh, Ali, Wael Esmat, Abdelmeguid, Mona Mohamed, Abdel-Gawad, Muhammad
Format: Article
Language:English
Subjects:
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692/4023
Body mass index
Bone Density
Bone mass
Bone mineral density
Calcium
Calcium (blood)
Cholestanes
Cross-Sectional Studies
Egypt - epidemiology
Fatty liver
Humanities and Social Sciences
Humans
Insulin
Liver diseases
multidisciplinary
Non-alcoholic Fatty Liver Disease - complications
Osteoporosis
Osteoporosis - complications
Osteoporosis - etiology
Parathyroid hormone
Phosphorus
Risk factors
Science
Science (multidisciplinary)
Vitamin D
Vitamins
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Summary:Nonalcoholic fatty liver disease (NAFLD) has been linked with a number of extra hepatic diseases and could be a potential risk factor of decreasing bone mineral density. To determine whether Upper Egyptian patients with NAFLD are at risk of developing osteoporosis. Cross sectional study was done on a total 100 individuals; 50 patients diagnosed with NAFLD (based on ultrasound imaging) crossed-matched with 50 individuals without NAFLD based on age, sex and body mass index. Bone mineral density, serum calcium and phosphorus levels, serum parathyroid hormone, serum vitamin D and fasting insulin level were assessed. Osteoporosis was prevalent in NAFLD patients versus to controls (19/50 vs. 0/50; P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-31256-w