The impact of the stress hyperglycemia ratio on the risk of contrast-associated acute kidney injury in patients undergoing coronary angiography: a large real-world cohort study

Contrast-associated acute kidney injury (CA-AKI) is an important complication in the perioperative period of coronary angiography (CAG). Dysglycemia is closely associated with the occurrence of CA-AKI. However, the association between stress hyperglycemia and CA-AKI in patients undergoing CAG remain...

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Published in:Diabetology and metabolic syndrome 2024-05, Vol.16 (1), p.107-107, Article 107
Main Authors: Li, Yuqi, Zhang, Liting, Liu, Weiqi, Deng, Jingru, Liu, Jin, Zhou, Yang, Feng, Li, Chen, Jiyan
Format: Article
Language:English
Subjects:
Age
Anemia
Angiography
Blood sugar
Cardiac patients
Cohort analysis
Confounding (Statistics)
Contrast-associated acute kidney injury
Coronary angiography
Creatinine
Diabetes
Glucose
Glycosylated hemoglobin
Heart attacks
Hemoglobin
Hyperglycemia
Kidney diseases
Kidneys
Medical imaging
Medical research
Medicine, Experimental
Population
Prediction models
Regression analysis
Stress hyperglycemia ratio
Transluminal angioplasty
Trinucleotide repeats
Variables
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Summary:Contrast-associated acute kidney injury (CA-AKI) is an important complication in the perioperative period of coronary angiography (CAG). Dysglycemia is closely associated with the occurrence of CA-AKI. However, the association between stress hyperglycemia and CA-AKI in patients undergoing CAG remains unclear. The study aims to investigate the association of the stress hyperglycemia ratio (SHR) and CA-AKI under CAG in a large real-world cohort. This was a retrospective observational study, and patients undergoing CAG were enrolled. SHR is calculated by dividing the random blood glucose with the estimated average glucose derived from the glycosylated hemoglobin (HbA1c), and subjects were divided into five groups according to SHR. The outcome was CA-AKI defined as an increase in serum creatinine of ≥ 0.3 mg/dL (26.5 μmol/L) or 1.5-fold higher than normal levels in 48 h. The association was assessed with logistic regression and restricted cubic spline analysis. In 19,965 participants (men: 73.3%, mean age: 63.1 ± 10.8 years) undergoing CAG, a total of 1,621 CA-AKI cases occurred. There were reverse J-shaped associations between the SHR and CA-AKI after adjustment for other confounding factors. Moreover, SHR improved the predictive effectiveness of the traditional Mehran score (AUC 0.65 vs 0.63, P 
ISSN:1758-5996
1758-5996
DOI:10.1186/s13098-024-01345-5