Validation of Different Nutritional Assessment Tools in Predicting Prognosis of Patients with Soft Tissue Spindle-Cell Sarcomas

Predicting outcomes in patients with soft tissue sarcoma (STS) is challenging. To improve these predictions, we retrospectively analyzed common nutritional assessment systems, including Glasgow prognostic score (GPS), Geriatric Nutritional Risk Index (GNRI), neutrophil⁻lymphocyte ratio (NLR), platel...

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Bibliographic Details
Published in:Nutrients 2018-06, Vol.10 (6), p.765
Main Authors: Sasaki, Hiromi, Nagano, Satoshi, Komiya, Setsuro, Taniguchi, Noboru, Setoguchi, Takao
Format: Article
Language:English
Subjects:
controlling nutritional (CONUT) score
Diagnosis
Geriatric Nutritional Risk Index (GNRI)
Glasgow prognostic score (GPS)
Health risk assessment
Medical prognosis
neutrophil–lymphocyte ratio (NLR)
Nutrition assessment
Patients
platelet–lymphocyte ratio (PLR)
Prognosis
Regression analysis
Risk analysis
Risk factors
Sarcoma
Soft tissue sarcoma
soft tissue sarcomas (STS)
Statistical models
Tissues
Tumors
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Summary:Predicting outcomes in patients with soft tissue sarcoma (STS) is challenging. To improve these predictions, we retrospectively analyzed common nutritional assessment systems, including Glasgow prognostic score (GPS), Geriatric Nutritional Risk Index (GNRI), neutrophil⁻lymphocyte ratio (NLR), platelet⁻lymphocyte ratio (PLR), and controlling nutritional (CONUT) score against outcomes in 103 patients with STS, of whom 15 (14.6%) died within 1 year of diagnosis. GPS, GNRI, NLR, PLR, and CONUT scores significantly differed between patients who died within one year and patients who lived longer. Binomial logistic regression analysis showed that male sex, older age at diagnosis, higher GPS, higher stage, and unresectable STS were risk factors for death within a year of diagnosis. Overall survival was evaluated by Cox proportional hazards models, which correlated higher NLR, higher PLR, larger maximum diameter of tumor, higher stage, and unresectable STS with poor prognosis. We next examined prognostic factors in the 93 patients with resectable STS, and found male sex, higher GPS, and higher stage were correlated with poor prognosis in these patients. Our findings suggest that GPS, NLR, and PLR are simple predictors of outcome in patients with STS. Nutritional therapies might improve their GPS and prognosis.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu10060765