TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review

Background. The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a rare oculorenal condition, mainly seen in children and women. The underlying cause of this disease is unknown. Case Presentation. We report a 24-year-old male without any past medical history, diagnosed with bilateral u...

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Bibliographic Details
Published in:Case reports in nephrology 2024-04, Vol.2024, p.1-6
Main Authors: Montejo-Hernández, Juan, Rico-Fontalvo, Jorge, Cabrales, Jose, Anand, Shuchi, Martínez-Ávila, María Cristina, Duran-Merino, Claudia, Arias-Restrepo, Luis, Gómez Duran, Camilo Andrés
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Biopsy
Blood
Case Report
Case reports
Creatinine
Edema
Histopathology
Laboratories
Nephrology
Ophthalmology
Pathophysiology
Patients
Proteins
Sarcoidosis
Systemic diseases
Tuberculosis
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Summary:Background. The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a rare oculorenal condition, mainly seen in children and women. The underlying cause of this disease is unknown. Case Presentation. We report a 24-year-old male without any past medical history, diagnosed with bilateral uveitis and azotemia. Biopsy revealed tubulointerstitial nephritis, consistent with TINU syndrome. Fluorescein angiogram revealed peripheral retinal vasculitis. Discussion. TINU is a rare disorder that needs to be distinguished from sarcoidosis, Sjogren’s disease, and tuberculosis. Treatment is indicated in patients with progressive renal insufficiency, consisting of steroid therapy. Most patients recover kidney function. Its early recognition is important to offer the best chance of organ preservation.
ISSN:2090-6641
2090-665X
DOI:10.1155/2024/3909755