The Impact of an Inactivated Hepatitis A Vaccine with One Dose in Brazil: A Retrospective Time-Series

In 2014, a recommended one-dose of inactivated hepatitis A vaccine was included in the Brazilian National Immunization Program targeting children 12-24 months. This decision addressed the low to intermediate endemicity status of hepatitis A across Brazil and the high rate of infection in children an...

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Bibliographic Details
Published in:Vaccines (Basel) 2021-04, Vol.9 (4), p.407
Main Authors: Bierrenbach, Ana Luiza, Choi, Yoonyoung, Batista, Paula de Mendonça, Serra, Fernando Brandão, Parellada, Cintia Irene, Julian, Guilherme Silva, Nakajima, Karina, Moreira, Thais das Neves Fraga
Format: Article
Language:English
Subjects:
Age groups
Children
Deactivation
Epidemics
Geographical distribution
Hepatitis
Hepatitis A
Immunization
Infections
Information systems
interrupted time-series analysis
Liver diseases
Mortality
national immunization program
Population
Reduction
Sanitation
Secondary analysis
Time series
Vaccination
Vaccines
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Summary:In 2014, a recommended one-dose of inactivated hepatitis A vaccine was included in the Brazilian National Immunization Program targeting children 12-24 months. This decision addressed the low to intermediate endemicity status of hepatitis A across Brazil and the high rate of infection in children and adolescents between 5 and 19 years old. The aim of the study was to conduct a time-series analysis on hepatitis A incidence across age groups and to assess the hepatitis A distribution throughout Brazilian geographic regions. An interrupted time-series analysis was performed to assess hepatitis A incidence rates before (2010-2013) and after (2015-2018) hepatitis A vaccine program implementation. The time-series analysis was stratified by age groups while a secondary analysis examined geographic distribution of hepatitis A cases. Overall incidence of hepatitis A decreased from 3.19/100.000 in the pre-vaccine period to 0.87/100.000 ( = 0.022) post-vaccine introduction. Incidence rate reduction was higher among children aged 1-4 years old, with an annual reduction of 67.6% in the post-vaccination period against a 7.7% annual reduction in the pre-vaccination period ( < 0.001). Between 2015 and 2018, the vaccination program prevented 14,468 hepatitis A cases. Our study highlighted the positive impact of a recommended one-dose inactivated hepatitis A vaccine for 1-4-years-old in controlling hepatitis A at national level.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines9040407