Synthesis of Mesoporous CuO Hollow Sphere Nanozyme for Paper-Based Hydrogen Peroxide Sensor

Point-of-care monitoring of hydrogen peroxide is important due to its wide usage in biomedicine, the household and industry. Herein, a paper sensor is developed for sensitive, visual and selective detection of H O using a mesoporous metal oxide hollow sphere as a nanozyme. The mesoporous CuO hollow...

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Bibliographic Details
Published in:Biosensors (Basel) 2021-07, Vol.11 (8), p.258
Main Authors: Cheng, Dong, Qin, Jing, Feng, Youyou, Wei, Jing
Format: Article
Language:English
Subjects:
Alzheimer's disease
Biosensing Techniques
Copper - analysis
Copper oxides
Environmental protection
Enzymes
Filter paper
Food security
Glucose
hollow sphere
Hydrogen peroxide
Hydrogen Peroxide - analysis
Ligands
mesoporous metal oxide
Metal oxides
Nanomaterials
Nanoparticles
nanozyme
paper sensor
Peroxidase
polyphenol
Pore size
Sensors
Smartphones
Spheres
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Summary:Point-of-care monitoring of hydrogen peroxide is important due to its wide usage in biomedicine, the household and industry. Herein, a paper sensor is developed for sensitive, visual and selective detection of H O using a mesoporous metal oxide hollow sphere as a nanozyme. The mesoporous CuO hollow sphere is synthesized by direct decomposition of copper-polyphenol colloidal spheres. The obtained mesoporous CuO hollow sphere shows a large specific surface area (58.77 m /g), pore volume (0.56 cm /g), accessible mesopores (5.8 nm), a hollow structure and a uniform diameter (~100 nm). Furthermore, they are proven to show excellent peroxidase-like activities with and values of 120 mM and 1.396 × 10 M·s , respectively. Such mesoporous CuO hollow spheres are then loaded on the low-cost and disposable filter paper test strip. The obtained paper sensor can be effectively used for detection of H O in the range of 2.4-150 μM. This work provides a new kind of paper sensor fabricated from a mesoporous metal oxide hollow sphere nanozyme. These sensors could be potentially used in bioanalysis, food security and environmental protection.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios11080258